Bihemispheric Transcranial Direct Current Stimulation Enhances Effector-Independent Representations of Motor Synergy and Sequence Learning
Bihemispheric Transcranial Direct Current Stimulation Enhances Effector-Independent Representations of Motor Synergy and Sequence Learning
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双半球经颅直流电刺激增强了运动协同和序列学习的效应器独立表示
DOI：
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发表时间：
2014
影响因子：
5.3
通讯作者：
J. Diedrichsen
中科院分区：
文献类型：
--
作者：
Sheena Waters;M. Husain;T. Wiestler;J. Diedrichsen
复杂的体力劳动--从扣衬衫纽扣到弹钢琴--基本上涉及两个部分：(1)产生特定的肌肉活动模式(这里称为“协同效应”)；(2)将这些活动串成有目的的序列。虽然经颅直流电刺激初级运动皮质(M1)可以增加运动序列的学习，但目前还不清楚它是否同样能促进运动协同学习。在这里，我们使用一种新的手形任务来确定tDCs对运动协同学习的影响，该任务需要产生困难的肌肉激活模式。采用双盲设计，在4d的重复左手构型训练中，将双侧半球tdcs应用于健康右利手受试者的M1。TDC增强了协同学习，随后导致更快和更同步的执行。这种影响在训练后至少持续了4周。在单独的受试者队列中对手指序列进行训练期间，也出现了与tDCs相关的定性相似的改善。此外，我们还确定了tdcs是否只促进了特定协同/序列的运动记忆的获得，或者它是否也促进了运动表征的更一般部分，这些部分可以转移到新的动作中。关键的是，我们观察到tdcs效应被概括到未经训练的手的构型和未训练的手指序列(即，非特异性)，以及未训练的手(即，与效应器无关)。因此，双半球TDC可能是神经康复训练方案的一个很有前途的补充，在这些方案中，广泛转移到日常任务是非常可取的。
Complex manual tasks—everything from buttoning up a shirt to playing the piano—fundamentally involve two components: (1) generating specific patterns of muscle activity (here, termed “synergies”); and (2) stringing these into purposeful sequences. Although transcranial direct current stimulation (tDCS) of the primary motor cortex (M1) has been found to increase the learning of motor sequences, it is unknown whether it can similarly facilitate motor synergy learning. Here, we determined the effects of tDCS on the learning of motor synergies using a novel hand configuration task that required the production of difficult muscular activation patterns. Bihemispheric tDCS was applied to M1 of healthy, right-handed human participants during 4 d of repetitive left-hand configuration training in a double-blind design. tDCS augmented synergy learning, leading subsequently to faster and more synchronized execution. This effect persisted for at least 4 weeks after training. Qualitatively similar tDCS-associated improvements occurred during training of finger sequences in a separate subject cohort. We additionally determined whether tDCS only improved the acquisition of motor memories for specific synergies/sequences or whether it also facilitated more general parts of the motor representations, which could be transferred to novel movements. Critically, we observed that tDCS effects generalized to untrained hand configurations and untrained finger sequences (i.e., were nonspecific), as well as to the untrained hand (i.e., were effector-independent). Hence, bihemispheric tDCS may be a promising adjunct to neurorehabilitative training regimes, in which broad transfer to everyday tasks is highly desirable.
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影响因子：
2.5
作者：
Lang, CE;Schieber, MH
通讯作者：
Schieber, MH
影响因子：
2.5
作者：
Rioult-Pedotti, M. -S.;Donoghue, J. P.;Dunaevsky, A.
通讯作者：
Dunaevsky, A.
影响因子：
2.5
作者：
Zarahn, Eric;Weston, Gregory D.;Krakauer, John W.
通讯作者：
Krakauer, John W.
影响因子：
2.5
作者：
Clark, David J.;Ting, Lena H.;Kautz, Steven A.
通讯作者：
Kautz, Steven A.
影响因子：
2.5
作者：
Dipietro, L.;Krebs, H. I.;Hogan, N.
通讯作者：
Hogan, N.