SIV-infected Chinese-origin rhesus macaques express specific MHC class I alleles in either elite controllers or normal progressors.

SIV-infected Chinese-origin rhesus macaques express specific MHC class I alleles in either elite controllers or normal progressors.
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DOI:
10.1111/j.1600-0684.2011.00487.x
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发表时间:
2011-08
影响因子:
0.7
通讯作者:
Mothé BR
Mothé BR
中科院分区:
农林科学4区
文献类型:
--
作者:
Wambua D;Henderson R;Solomon C;Hunter M;Marx P;Sette A;Mothé BR

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我们对12只感染SIV的中国猕猴的全部MHC I类等位基因组成进行了表征。在感染的动物中存在几个MHC I类等位基因,结果各不相同,要么是精英控制,要么是正常发展为艾滋病。这些MHC I类等位基因可能会被证明是更多特征的有趣目标。
We characterized twelve SIV-infected Chinese-origin rhesus macaques for their entire MHC class I allele composition. Several MHC class I alleles were present in animals with varying outcomes of infections, either elite control or normal progression to AIDS disease. These MHC class I alleles may prove interesting targets for additional characterization.
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