Novel analysis of sleep patterns in rats separates periods of vigilance cycling from long-duration wake events.
Novel analysis of sleep patterns in rats separates periods of vigilance cycling from long-duration wake events.
复制标题
DOI：
10.1016/j.bbr.2008.09.003
复制
发表时间：
2009-01-23
影响因子：
2.7
通讯作者：
Mukherjee, Sanjib
中科院分区：
文献类型：
--
作者：
Simasko, Steven M.;Mukherjee, Sanjib
关键词：
老鼠是多相睡眠者。然而，一个睡眠片段何时结束，另一个睡眠片段何时开始的正式定义还没有提出。在本研究中，我们检查了唤醒事件持续时间的分布，并根据此分布得出结论，有多个组件的唤醒。如果觉醒发作超过300秒，则将觉醒发作分配为长持续时间觉醒（LDW），如果发作小于300秒，则将其分配为短暂觉醒（BW）。在仔细分析BW与LDW中的EEG功率谱时，发现了对这种分离的进一步支持。然后，我们使用LDW事件将一个睡眠事件与另一个睡眠事件分开。我们称之为睡眠发作警觉循环（VC），因为大鼠是短暂清醒（BW），慢波睡眠（SWS）和快速眼动睡眠（REMS）之间的警觉状态循环。我们发现VC的特性在光周期和暗周期是不同的。我们进一步发现，随着VC事件的进展，SWS压力减少，但在REMS中花费的时间增加。这些结果表明，VC发作是调节和有意义的大鼠的睡眠行为。LDW和VC的概念的使用提供了额外的见解，在大鼠的睡眠模式的描述，可能是重要的，在这种动物的睡眠行为的完整描述的发展。
Rats are polyphasic sleepers. However, a formal definition of when one sleep episode ends and another begins has not been put forth. In the present study we examine the distribution of wake episode durations and based on this distribution conclude there are multiple components of wake. If the wake episode exceeds 300 sec the wake episode is assigned to long duration wake (LDW), if the episode is less than 300 sec it is assigned to brief wake (BW). Further support for this separation was found in close analysis of the EEG power spectrum in BW versus LDW. We then used LDW episodes to separate one sleep episode from another. We term the sleep episodes vigilance cycling (VC) because the rat is cycling between the vigilance states of brief wake (BW), slow-wave sleep (SWS), and rapid-eye movement sleep (REMS). We find that the characteristics of VC are different in the light period versus the dark period. We further find that as VC episodes progress, SWS pressure lessens, but the amount of time spent in REMS increases. These findings suggest that VC episodes are regulated and meaningful to the sleep behavior of rats. The use of the concepts of LDW and VC provides additional insights into the description of sleep patterns in rats that may be important in the development of a complete description of sleep behavior in this animal.
登录
查看更多内容
影响因子：
56.9
作者：
Porkka-Heiskanen, T;Strecker, RE;McCarley, RW
通讯作者：
McCarley, RW
影响因子：
16.2
作者：
Willie, JT;Chemelli, RM;Yanagisawa, M
通讯作者：
Yanagisawa, M
DOI：
10.1073/pnas.0408242101
发表时间：
2004-12-14
影响因子：
11.1
作者：
Lo, CC;Chou, T;Ivanov, PC
通讯作者：
Ivanov, PC
影响因子：
3.4
作者：
Blumberg, Mark S.;Coleman, Cassandra M.;Shaw, Cynthia
通讯作者：
Shaw, Cynthia
影响因子：
4.4
作者：
Lahl, Olaf;Wispel, Christiane;Pietrowsky, Reinhard
通讯作者：
Pietrowsky, Reinhard