The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer.
The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer.
复制标题
DOI：
10.4161/rna.7.3.11837
复制
发表时间：
2010-05
期刊：
影响因子：
4.1
通讯作者：
Rosen JM
中科院分区：
文献类型：
--
作者：
Greene SB;Herschkowitz JI;Rosen JM
最近的研究表明，miR-205在正常发育和癌症中都有作用，然而关于其功能的相互矛盾的报道说明了其调控和靶点的复杂性。此外，发现miR-205在来自小鼠乳腺的干细胞富集群体中高度表达，因此可能在正常乳腺干细胞维持中发挥作用。miR-205在肿瘤形成和转移中所起的作用可能是环境依赖性的，因为报告已经表明它可以作为肿瘤抑制基因或癌基因起作用。miR-205在指导干细胞命运中的作用仍然未知。
Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.
登录
查看更多内容
影响因子：
64.8
作者：
Lu, J;Getz, G;Golub, TR
通讯作者：
Golub, TR
影响因子：
11.2
作者：
Iorio, MV;Ferracin, M;Croce, CM
通讯作者：
Croce, CM
影响因子：
11.2
作者：
Gandellini, Paolo;Folini, Marco;Zaffaroni, Nadia
通讯作者：
Zaffaroni, Nadia
影响因子：
11.2
作者：
Sempere, Lorenzo F.;Christensen, Mette;Cole, Charles N.
通讯作者：
Cole, Charles N.
影响因子：
30.8
作者：
Chen, JF;Mandel, EM;Wang, DZ
通讯作者：
Wang, DZ