Regional quantification of myocardial mechanics in rat using 3D cine DENSE cardiovascular magnetic resonance.
Regional quantification of myocardial mechanics in rat using 3D cine DENSE cardiovascular magnetic resonance.
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DOI：
10.1002/nbm.3733
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发表时间：
2017-08
影响因子：
2.9
通讯作者：
Wenk, Jonathan F.
中科院分区：
文献类型：
--
作者：
Zhang, Xiaoyan;Liu, Zhan-Qiu;Singh, Dara;Wehner, Gregory J.;Powell, David K.;Campbell, Kenneth S.;Fornwalt, Brandon K.;Wenk, Jonathan F.
大鼠模型在心脏研究中发挥着越来越重要的作用。然而，一个详细的配置文件的区域心脏力学，如应变和扭转，是缺乏大鼠。我们假设，健康大鼠左心室（LV）表现出心脏力学的区域差异，这是正常功能的一部分。在这项研究中，图像的左心室三维电影位移编码与刺激回波（DENSE）心血管磁共振（CMR）在10只健康大鼠。为了评价局部心脏力学，将LV分为基底部、心室中部和心尖部。左心室中部的心肌进一步分为四个壁段（即，隔膜、下、侧和前）和三个透壁层（即，内膜下、中层心肌和心外膜下）。6个拉格朗日应变分量（即，Err、Ecc、Ell、Ecl、Erl和Ecr）根据3D位移场计算，并在每个感兴趣区域内取平均值。使用周向-纵向剪切角对扭转进行量化。虽然收缩期峰值Ecl在心室中部和心尖部之间不同，但收缩期峰值应变的其他5个分量在基底部、心室中部和心尖部是相似的。左室中层心肌Ecc从内膜下到心外膜下逐渐降低。Ell显示了四个壁段之间的显著差异，其中下段的幅度最大。Err在四个壁段中是均匀的。Ecl沿着透壁方向和壁段之间变化，而Erl仅在壁段之间不同。Erc与显著变化无关。扭转也沿着透壁方向和壁段之间的变化。这些结果为健康大鼠心脏区域收缩功能提供了基本见解，并为未来研究疾病或治疗引起的区域变化奠定了基础。
Rat models have assumed an increasingly important role in cardiac research. However, a detailed profile of regional cardiac mechanics, such as strains and torsion, is lacking in rats. We hypothesized that healthy rat left ventricles (LV) exhibit regional differences in cardiac mechanics, which are part of normal function. In this study, images of the LV were obtained with 3D cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR) in 10 healthy rats. To evaluate regional cardiac mechanics, the LV was divided into basal, mid-ventricular, and apical regions. The myocardium at the mid-LV was further partitioned into four wall segments (i.e., septal, inferior, lateral, and anterior) and three transmural layers (i.e., sub-endocardium, mid-myocardium, and sub-epicardium). The 6 Lagrangian strain components (i.e., Err, Ecc, Ell, Ecl, Erl, and Ecr) were computed from the 3D displacement field and averaged within each region of interest. Torsion was quantified using the circumferential-longitudinal shear angle. While peak systolic Ecl differed between the mid-ventricle and apex, the other 5 components of peak systolic strain were similar across the base, mid-ventricle, and apex. In the mid-LV myocardium, Ecc decreased gradually from the sub-endocardial to the sub-epicardial layer. Ell demonstrated significant differences between the four wall segments with the largest magnitude in the inferior segment. Err was uniform among the four wall segments. Ecl varied along the transmural direction and among wall segments, whereas Erl differed only among the wall segments. Erc was not associated with significant variations. Torsion also varied along the transmural direction and among wall segments. These results provide fundamental insights into the regional contractile function of healthy rat hearts, and form the foundation for future studies on regional changes induced by disease or treatments.
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DOI：
10.1152/ajpheart.00406.2010
发表时间：
2010-11-01
影响因子：
4.8
作者：
Chen, Yong;Somji, Aleefia;Stelzer, Julian E.
通讯作者：
Stelzer, Julian E.
影响因子：
20.1
作者：
Glukhov AV;Fedorov VV;Lou Q;Ravikumar VK;Kalish PW;Schuessler RB;Moazami N;Efimov IR
通讯作者：
Efimov IR
影响因子：
3.3
作者：
Zhong, Xiaodong;Helm, Patrick A.;Epstein, Frederick H.
通讯作者：
Epstein, Frederick H.
影响因子：
6.4
作者：
Haggerty, Christopher M.;Kramer, Sage P.;Fornwalt, Brandon K.
通讯作者：
Fornwalt, Brandon K.
影响因子：
10.9
作者：
Spottiswoode BS;Zhong X;Lorenz CH;Mayosi BM;Meintjes EM;Epstein FH
通讯作者：
Epstein FH