Seeing the forest for the trees: annotating small RNA producing genes in plants.
Seeing the forest for the trees: annotating small RNA producing genes in plants.
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DOI:
10.1016/j.pbi.2014.02.008
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发表时间:
2014-04
影响因子:
9.5
通讯作者:
Axtell MJ
中科院分区:
文献类型:
--
作者:
Coruh C;Shahid S;Axtell MJ
A key goal in genomics is the complete annotation of the expressed regions of the genome. In plants, substantial portions of the genome make regulatory small RNAs produced by Dicer-Like (DCL) proteins and utilized by Argonaute (AGO) proteins. These include miRNAs and various types of endogenous siRNAs. Small RNA-seq, enabled by cheap and fast DNA sequencing, has produced an enormous volume of data on plant miRNA and siRNA expression in recent years. In this review, we discuss recent progress in using small RNA-seq data to produce stable and reliable annotations of miRNA and siRNA genes in plants. In addition, we highlight key goals for the future of small RNA gene annotation in plants.
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