The Role of microRNAs in Development of Colitis-Associated Colorectal Cancer.
The Role of microRNAs in Development of Colitis-Associated Colorectal Cancer.
复制标题
microRNA在结肠炎相关结直肠癌发展中的作用。
DOI：
10.3390/ijms22083967
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发表时间：
2021-04-12
影响因子：
5.6
通讯作者：
Yau TO
中科院分区：
文献类型：
--
作者：
Bocchetti M;Ferraro MG;Ricciardiello F;Ottaiano A;Luce A;Cossu AM;Scrima M;Leung WY;Abate M;Stiuso P;Caraglia M;Zappavigna S;Yau TO
结直肠癌(CRC)是全球第三大致死性癌症，炎症性肠病(IBD)是结直肠癌发生的关键因素之一。IBD是导致有利于转化的非生理性和持续的慢性炎症环境的原因。MicroRNAs(MiRNAs)是一类高度保守的单链短链(18-25个核苷酸)非编码RNA，在结直肠癌和IBD中都有广泛的讨论。然而，miRNAs在结肠炎相关性结直肠癌(CAC)发生发展中的作用尚不清楚。本文主要综述CAC中上调的miR-18a、miR-19a、miR-21、miR-31、miR-155和miR-214以及下调的miR-124、miR-193a-3p和miR-139-5p，以及它们在慢性结肠炎诱导的癌变过程中基因表达调控中的作用，包括程序性细胞死亡途径。这些miRNAs的异常表达可用于CAC的早期诊断、预测疗效和精确治疗。
Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.
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