Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis.
Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis.
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Fas/FasL 基因多态性与肌肉骨骼退行性疾病之间的关联：荟萃分析
DOI：
10.1186/s12891-018-2057-z
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发表时间：
2018-05-07
影响因子：
2.3
通讯作者：
Shao Z
中科院分区：
文献类型：
--
作者：
Huang D;Xiao J;Deng X;Ma K;Liang H;Shi D;Wu F;Shao Z
研究背景Fas（rs1800682，rs2234767）和FasL（rs5030772，rs763110）基因多态性可能与骨关节炎（OA）、椎间盘退变（IVDD）和类风湿性关节炎（RA）等肌肉骨骼退行性疾病（MSDD）的发病风险有关。然而，不同研究的数据并不一致。在此，我们旨在精心总结和探讨Fas之间的关联方法检索PubMed、Web of Science、Embase、Scopus和Medline中的英文文献，维普、SinoMed、万方和中国知网（CNKI）中的中文文献，检索截止日期为2017年8月21日。所有研究均为病例对照研究。我们计算了合并比值比（OR）和95%置信区间（95%CI），以评估Fas相关性的强度。（rs1800682，rs2234767）和FasL rs5030772，rs763110多态性与MSDD风险。结果rs1800682的11项合格研究，1930例病例和1720例对照，本分析纳入了rs2234767的6项合格研究（1794例病例和1909例对照）、rs5030772的3项合格研究（367例病例和313例对照）和rs763110的8项合格研究（2010例病例和2105例对照）。结果表明，Fas基因的G等位基因（rs1800682）与纯合子和隐性模型中IVDD的风险增加有关。在等位基因和隐性模型中，Fas的G等位基因（rs2234767）与RA风险降低相关，但与OA风险增加相关。此外，FasL的T等位基因（rs763110）在所有模型中与IVDD风险降低相关。结论Fas（rs1800682）和FasL（rs763110）基因多态性与IVDD的发病风险相关，Fas（rs2234767）基因多态性与OA和RA的易感性相关。Fas（rs1800682）和Fas（rs2234767）与中国人MSDD的发病可能性更大。对于高加索人种和中国人种来说，FasL（rs763110）与MSDD的进展有关。但FasL（rs5030772）可能与任何类型的MSDD或任何种族群体无关。
BackgroundIt was reported that Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) gene polymorphism might be related to the risk of musculoskeletal degenerative diseases (MSDD), such as osteoarthritis (OA), intervertebral disc degeneration (IVDD) and rheumatoid arthritis (RA). However, data from different studies was inconsistent. Here we aim to elaborately summarize and explore the association between the Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) and MSDD.MethodsLiteratures were selected from PubMed, Web of Science, Embase, Scopus and Medline in English and VIP, SinoMed, Wanfang and the China National Knowledge Infrastructure (CNKI) in Chinese up to August 21, 2017. All the researches included are case-control studies about human. We calculated the pooled odds ratios (ORs) with 95% confidence intervals (95% CI) to evaluate the strengths of the associations of Fas (rs1800682, rs2234767) and FasL (rs5030772, rs763110) polymorphisms with MSDD risk.ResultsEleven eligible studies for rs1800682 with 1930 cases and 1720 controls, 6 eligible studies for rs2234767 with 1794 cases and 1909 controls, 3 eligible studies for rs5030772 with 367 cases and 313 controls and 8 eligible studies for rs763110 with 2010 cases and 2105 controls were included in this analysis. The results showed that the G allele of Fas (rs1800682) is associated with an increased risk of IVDD in homozygote and recessive models. The G allele of Fas (rs2234767) is linked to a decreased risk of RA but an enhanced risk of OA in allele and recessive models. In addition, the T allele of FasL (rs763110) is correlated with a reduced risk of IVDD in all of models. However, no relationship was found between FasL (rs5030772) and these three types of MSDD in any models.ConclusionsFas (rs1800682) and FasL (rs763110) polymorphism were associated with the risk of IVDD and Fas (rs2234767) was correlated to the susceptibility of OA and RA. Fas (rs1800682) and Fas (rs2234767) are more likely to be associated with MSDD for Chinese people. FasL (rs763110) is related to the progression of MSDD for both Caucasoid and Chinese race groups. But FasL (rs5030772) might not be associated with any types of MSDD or any race groups statistically.
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影响因子：
1.8
作者：
Martirosyan NL;Patel AA;Carotenuto A;Kalani MY;Belykh E;Walker CT;Preul MC;Theodore N
通讯作者：
Theodore N
影响因子：
5.5
作者：
Coakley, G;Manolios, N;Lanchbury, JS
通讯作者：
Lanchbury, JS
影响因子：
1.4
作者：
Kobak, S.;Berdeli, A.
通讯作者：
Berdeli, A.
DOI：
10.5114/aoms.2015.53963
发表时间：
2017-03-01
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Ozdemirkiran FG;Nalbantoglu S;Gokgoz Z;Payzin BK;Vural F;Cagirgan S;Berdeli A
通讯作者：
Berdeli A
影响因子：
168.9
作者：
Glyn-Jones, S.;Palmer, A. J. R.;Carr, A. J.
通讯作者：
Carr, A. J.