The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link.
The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link.
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DOI：
10.3389/fendo.2015.00077
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发表时间：
2015
影响因子：
5.2
通讯作者：
Hursting SD
中科院分区：
文献类型：
--
作者：
Bowers LW;Rossi EL;O'Flanagan CH;deGraffenried LA;Hursting SD
许多流行病学和临床前研究表明，胰岛素/胰岛素样生长因子（IGF）系统在几种类型的癌症的发生和发展中起着关键作用。胰岛素/IGF信号传导与慢性低度炎症合作，也是肥胖促癌作用的重要贡献者。然而，针对该系统的不同组分的药物的临床试验产生了很大程度上令人失望的结果，这可能是由于缺乏预测性生物标志物的使用和联合治疗方案设计的问题。通过仔细关注可能的患者应答者和最佳药物组合的识别，未来试验的结果可能会得到改善。鉴于已知胰岛素/IGF信号传导有助于肥胖相关癌症，因此有必要进一步研究针对该系统及其下游效应物的药物在肥胖患者人群中的疗效。
Numerous epidemiological and pre-clinical studies have demonstrated that the insulin/insulin-like growth factor (IGF) system plays a key role in the development and progression of several types of cancer. Insulin/IGF signaling, in cooperation with chronic low-grade inflammation, is also an important contributor to the cancer-promoting effects of obesity. However, clinical trials for drugs targeting different components of this system have produced largely disappointing results, possibly due to the lack of predictive biomarker use and problems with the design of combination therapy regimens. With careful attention to the identification of likely patient responders and optimal drug combinations, the outcome of future trials may be improved. Given that insulin/IGF signaling is known to contribute to obesity-associated cancer, further investigation regarding the efficacy of drugs targeting this system and its downstream effectors in the obese patient population is warranted.
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影响因子：
9.7
作者：
Bruchim, Ilan;Sarfstein, Rive;Werner, Haim
通讯作者：
Werner, Haim
DOI：
10.1158/1078-0432.ccr-13-3448
发表时间：
2014-06-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Beltran PJ;Calzone FJ;Mitchell P;Chung YA;Cajulis E;Moody G;Belmontes B;Li CM;Vonderfecht S;Velculescu VE;Yang G;Qi J;Slamon DJ;Konecny GE
通讯作者：
Konecny GE
影响因子：
11.5
作者：
Atzori, Francesco;Tabernero, Josep;Baselga, Jose
通讯作者：
Baselga, Jose
影响因子：
2.8
作者：
Caso, Jorge;Masko, Elizabeth M.;Thomas, Jean A., II;Poulton, Susan H.;Dewhirst, Mark;Pizzo, Salvatore V.;Freedland, Stephen J.
通讯作者：
Freedland, Stephen J.
影响因子：
11.2
作者：
Buck, Elizabeth;Eyzaguirre, Alexandra;Ji, Qun-Sheng
通讯作者：
Ji, Qun-Sheng