TROP2 overexpression in colorectal liver oligometastases is associated with poor prognosis after liver resection.
TROP2 overexpression in colorectal liver oligometastases is associated with poor prognosis after liver resection.
复制标题
结直肠肝寡转移中 TROP2 过表达与肝切除后不良预后相关
DOI：
10.1177/1758835919897543
复制
发表时间：
2019
影响因子：
4.9
通讯作者：
Fang Y
中科院分区：
文献类型：
--
作者：
Peng J;Ou Q;Deng Y;Xiao B;Zhang L;Li J;Li Y;Wan D;Lu Z;Fang Y
本研究的目的是评估滋养层抗原蛋白2（TROP 2）在肝寡转移中的表达及其对行肝切除术的结直肠肝寡转移（CLO）患者的预后价值。我们回顾性选择了1999年6月至2016年12月期间接受根治性肝切除术的129例连续CLO患者。采用免疫组化（IHC）法检测石蜡包埋标本中TROP 2的表达。采用Kaplan-Meier法和log-rank检验分析无复发生存期（RFS）和总生存期（OS），采用考克斯回归模型分析独立预后因素。TROP 2在72.9%（94/129）的肝少转移组织中表达。TROP 2在原发肿瘤和肝寡转移瘤中的表达呈显著正相关（r = 0.758，p < 0.001）。生存分析表明，与TROP 2低表达的CLO患者相比，TROP 2高表达的CLO患者的3年RFS（44.2%对66.4%，p = 0.007）和3年OS率（70.3%对85.4%，p = 0.035）更差。多变量分析表明，TR 0 P2高表达与不良RFS [风险比（HR）= 2.017; 95%置信区间（CI）1.198-3.396; p = 0.023]和OS（HR = 2.090; 95%CI 1.037-4.214; p = 0.039）独立相关。基因表达谱分析表明，高表达的TROP 2与TNFα信号通过NF-κB，炎症反应和上皮间质转化（EMT）。TROP 2过表达与接受肝切除术的CLO患者的肿瘤学预后不良相关。检测TROP 2的表达对指导CLO患者的术后治疗具有重要意义。
The aim of this study was to assess trophoblast antigen protein 2 (TROP2) expression in liver oligometastases and its prognostic value for colorectal liver oligometastasis (CLO) patients undergoing liver resection. We retrospectively selected 129 consecutive CLO patients who underwent curative liver resection between June 1999 and December 2016. Immunohistochemistry (IHC) was performed to detect TROP2 expression in paraffin-embedded specimens. Recurrence-free survival (RFS) and overall survival (OS) were analyzed using the Kaplan–Meier method and log-rank test, and independent prognostic factors were identified with Cox regression modeling. TROP2 was expressed in 72.9% (94/129) of liver oligometastatic tissues. TROP2 expression in primary tumors and liver oligometastases was significantly positively correlated (r = 0.758, p < 0.001). Survival analysis indicated that CLO patients with high TROP2 expression had worse 3-year RFS (44.2% versus 66.4%, p = 0.007) and 3-year OS rates (70.3% versus 85.4%, p = 0.035) than did those with low TROP2 expression. Multivariate analysis indicated that high TROP2 expression was independently associated with poor RFS [hazard ratio (HR) = 2.017; 95% confidence interval (CI) 1.198–3.396; p = 0.023] and OS (HR = 2.090; 95% CI 1.037–4.214; p = 0.039). Gene expression profile analysis indicated that high TROP2 expression was associated with TNFα signaling via NF-κB, the inflammatory response and epithelial–mesenchymal transition (EMT). TROP2 overexpression was associated with an unfavorable oncologic prognosis in patients with CLO undergoing liver resection. Detecting TROP2 expression may be valuable for guiding postoperative treatment among CLO patients.
登录
查看更多内容
MicroRNA-105 参与 TNF-α 相关的肿瘤微环境，增强结直肠癌的进展。
影响因子：
9
作者：
Shen, Zetao;Zhou, Rui;Zhao, Liang
通讯作者：
Zhao, Liang
影响因子：
4.2
作者：
Hou J;Lv A;Deng Q;Zhang G;Hu X;Cui H
通讯作者：
Cui H
影响因子：
--
作者：
Peng J;Ou Q;Wu X;Zhang R;Zhao Q;Jiang W;Lu Z;Wan D;Pan Z;Fang Y
通讯作者：
Fang Y
影响因子：
--
作者：
Reyes DK;Pienta KJ
通讯作者：
Pienta KJ
结直肠肝转移患者的转归：1,613例连续病例分析
影响因子：
3.7
作者：
Zhu Dexiang;Ren Li;Xu Jianmin
通讯作者：
Xu Jianmin