The enzymes of bacterial census and censorship.
The enzymes of bacterial census and censorship.
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DOI:
10.1016/j.tibs.2011.10.001
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发表时间:
2012-01
影响因子:
13.8
通讯作者:
Tipton, Peter A.
中科院分区:
文献类型:
--
作者:
Fast, Walter;Tipton, Peter A.
N-Acyl-l-homoserine lactones (AHLs) are a major class of quorum sensing signals used by Gram-negative bacteria to regulate gene expression in a population-dependent manner, thereby enabling group behavior. Enzymes capable of generating and catabolizing AHL signals are of significant interest for the study of microbial ecology and quorum-sensing pathways, for understanding the systems that bacteria have evolved to interact with small molecule signals, and for their possible use in therapeutic and industrial applications. The recent structural and functional studies reviewed here provide detailed insight into the chemistry and enzymology of bacterial communication.
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