The enzymes of bacterial census and censorship.

The enzymes of bacterial census and censorship.
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DOI:
10.1016/j.tibs.2011.10.001
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发表时间:
2012-01
影响因子:
13.8
通讯作者:
Tipton, Peter A.
Tipton, Peter A.
中科院分区:
生物学1区
文献类型:
--
作者:
Fast, Walter;Tipton, Peter A.

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N-酰基-L-高丝氨酸内酯(AHL)是革兰氏阴性菌使用的一类主要的群体感应信号,以群体依赖的方式调节基因表达,从而实现群体行为。能够产生和分解AHL信号的酶对于研究微生物生态学和群体感应途径、了解细菌进化成与小分子信号相互作用的系统以及它们可能在治疗和工业应用中的应用具有重要意义。这里综述的最近的结构和功能研究为细菌通讯的化学和酶学提供了详细的见解。
N-Acyl-l-homoserine lactones (AHLs) are a major class of quorum sensing signals used by Gram-negative bacteria to regulate gene expression in a population-dependent manner, thereby enabling group behavior. Enzymes capable of generating and catabolizing AHL signals are of significant interest for the study of microbial ecology and quorum-sensing pathways, for understanding the systems that bacteria have evolved to interact with small molecule signals, and for their possible use in therapeutic and industrial applications. The recent structural and functional studies reviewed here provide detailed insight into the chemistry and enzymology of bacterial communication.
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