Occurrence of capsular polysaccharide/adhesin among clinical isolates of coagulase-negative staphylococci.

Occurrence of capsular polysaccharide/adhesin among clinical isolates of coagulase-negative staphylococci.
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凝固酶阴性葡萄球菌临床分离株中荚膜多糖/粘附素的出现。

DOI:
10.1093/infdis/168.5.1211
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发表时间:
1993
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Pier,GB
Pier,GB
中科院分区:
--
文献类型:
--
作者:
Muller,E;Takeda,S;Shiro,H;Goldmann,D;Pier,GB

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分析凝固酶阴性葡萄球菌临床分离株的荚膜多糖/粘附(PS/A)和细胞外生物膜或粘液。151分析,103(68%)产生PS/A和69(46%)的细胞外粘液; 87%的粘液生产菌株PSjA。除腹膜炎外,在所有临床感染的分离株中,PS/A阳性分离株在15分钟后与硅胶弹性体导管1.5 cm段的菌落形成单位比PS/A阴性分离株显著(P<0.001)更多。由于42%的PS/A阳性分离株为粘液阴性,因此粘液阳性分离株的粘附性并不比粘液阴性分离株高。因此,PS/A表达在凝固酶阴性葡萄球菌的临床分离株中很常见,占大多数粘液阳性和一部分粘液阴性分离株。
Clinical isolates of coagulase-negative staphylococci were analyzed for elaboration of the capsular polysaccharidejadhesion (PS/A) and extracellular biofilm or slime. Of the 151 analyzed, 103 (68%) produced PS/A and 69 (46%) made extracellular slime; 87% of the slime-producing isolates made PSjA. Among isolates from all clinical infections examined except peritonitis, PS/A-positive isolates bound significantly (P< .001) more colony-forming units after 15 min to 1.5-cm segments of silicone-elastomer catheter than did PS/A-negative isolates. Slime-positive isolates were not more adherent than slime-negative isolates, because 42% of the PS/A-positive isolates were slime-negative. Thus, PS/A expression is common among clinical isolates of coagulase-negative staphylococci, accounting for most slime-positive and a proportion of slime-negative isolates.
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