Similar frequency of autoantibodies against pneumocytes type II and Clara cells in patients with interstitial lung diseases and healthy persons
Similar frequency of autoantibodies against pneumocytes type II and Clara cells in patients with interstitial lung diseases and healthy persons
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间质性肺疾病患者和健康人中抗 II 型肺细胞和 Clara 细胞自身抗体的频率相似
DOI：
10.1007/bf01644760
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
N. Zöllner
中科院分区：
文献类型：
--
作者：
R. Erlinger;G. Rauh;J. Behr;U. Schumacher;U. Welsch;N. Zöllner
几项实验结果提示间质性肺病与自身抗体之间存在联系。本文对103例特发性肺纤维化（IPF）患者（10例IPF、23例M.用间接免疫荧光法检测了18例类风湿性关节炎（RA）患者和52例健康对照者肺组织中抗Ⅱ型肺细胞和Clara细胞的自身抗体。这些针对两种细胞类型的抗体是肺细胞II型和Clara细胞中共同抗原的额外证据。自身抗体在4组中的出现频率相似（IPF：20%，M. Boeck：26.1%，RA：22.2%和23.1%的健康对照）。因此，未发现抗体与间质性肺疾病之间存在显著相关性。然而，本研究不能排除抗体在疾病发病机制中的作用。作为间质性肺疾病发展参数的可能作用应通过前瞻性随访研究的形式进行进一步研究。
SummarySeveral experimental findings suggest an association between interstitial lung diseases and autoantibodies. Antibodies against lung tissue including pneumocytes type II in patients suffering from idiopathic pulmonary fibrosis (IPF) were reported in recent years.In this investigation the serum of 103 persons (10 with IPF, 23 with M. Boeck, 18 with rheumatoid arthritis (RA) and 52 healthy controls) was examined for autoantibodies against pneumocytes type II and Clara cells by indirect immunofluorescence on human lung tissue. These antibodies against both cell types are an additional proof for common antigens in pneumocytes type II and Clara cells. The autoantibodies were present in similar frequency in the 4 groups (IPF: 20%, M. Boeck: 26.1%, RA: 22.2% and 23.1% of the healthy controls). So no significant association was found between the antibodies and the interstitial lung diseases. A role of the antibodies in the pathogenesis of the diseases, however, can not be excluded by this study. A possible role as parameter of development of interstitial lung diseases should be subject to further investigations in form of a prospective follow up study.
表面活性剂蛋白 SP28-36 的单克隆抗体通过免疫荧光标记犬 II 型和非纤毛细支气管细胞。
DOI：
10.1164/ajrccm/137.2.399
发表时间：
1988
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Williams,MC;Hawgood,S;Schenk,DB;Lewicki,J;Phelps,MN;Benson,B
通讯作者：
Benson,B