The rainbow trout genome provides novel insights into evolution after whole-genome duplication in vertebrates.
The rainbow trout genome provides novel insights into evolution after whole-genome duplication in vertebrates.
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DOI：
10.1038/ncomms4657
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发表时间：
2014-04-22
影响因子：
16.6
通讯作者：
Guiguen, Yann
中科院分区：
文献类型：
--
作者：
Berthelot, Camille;Brunet, Frederic;Chalopin, Domitille;Juanchich, Amelie;Bernard, Maria;Noel, Benjamin;Bento, Pascal;Da Silva, Corinne;Labadie, Karine;Alberti, Adriana;Aury, Jean-Marc;Louis, Alexandra;Dehais, Patrice;Bardou, Philippe;Montfort, Jerome;Klopp, Christophe;Cabau, Cedric;Gaspin, Christine;Thorgaard, Gary H.;Boussaha, Mekki;Quillet, Edwige;Guyomard, Rene;Galiana, Delphine;Bobe, Julien;Volff, Jean-Nicolas;Genet, Carine;Wincker, Patrick;Jaillon, Olivier;Roest Crollius, Hugues;Guiguen, Yann
脊椎动物的进化是由几轮全基因组复制（WGD）形成的，这些复制通常被认为与适应性辐射和进化创新有关。由于额外一轮的WGD，虹鳟鱼基因组提供了一个独特的机会来研究重复的脊椎动物基因组的早期进化命运。在这里，我们表明，经过1亿年的进化，这两个祖先的亚基因组仍然非常共线，尽管失去了一半的重复蛋白质编码基因，主要是通过假基因化。与此形成鲜明对比的是，几乎所有的miRNA基因都以重复拷贝的形式保留下来。缓慢和逐步的再二倍体化过程的特点，挑战了目前的假设，即WGD是其次是大规模和快速的基因组重组和基因缺失。 虽然全基因组复制（WGD）是罕见的事件，但它们在塑造脊椎动物进化中起着重要作用。在这里，作者对虹鳟鱼基因组进行了测序，并表明WGD后的再二倍体化以缓慢和逐步的方式发生。
Vertebrate evolution has been shaped by several rounds of whole-genome duplications (WGDs) that are often suggested to be associated with adaptive radiations and evolutionary innovations. Due to an additional round of WGD, the rainbow trout genome offers a unique opportunity to investigate the early evolutionary fate of a duplicated vertebrate genome. Here we show that after 100 million years of evolution the two ancestral subgenomes have remained extremely collinear, despite the loss of half of the duplicated protein-coding genes, mostly through pseudogenization. In striking contrast is the fate of miRNA genes that have almost all been retained as duplicated copies. The slow and stepwise rediploidization process characterized here challenges the current hypothesis that WGD is followed by massive and rapid genomic reorganizations and gene deletions. Although whole-genome duplications (WGDs) are rare events, they have an important role in shaping vertebrate evolution. Here, the authors sequence the rainbow trout genome and show that rediploidization after WGD occurs in a slow and stepwise manner.
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影响因子：
1.7
作者：
Jurka, J;Kapitonov, VV;Walichiewicz, J
通讯作者：
Walichiewicz, J
影响因子：
4.4
作者：
Aury JM;Cruaud C;Barbe V;Rogier O;Mangenot S;Samson G;Poulain J;Anthouard V;Scarpelli C;Artiguenave F;Wincker P
通讯作者：
Wincker P
影响因子：
12.3
作者：
Denoeud F;Aury JM;Da Silva C;Noel B;Rogier O;Delledonne M;Morgante M;Valle G;Wincker P;Scarpelli C;Jaillon O;Artiguenave F
通讯作者：
Artiguenave F
影响因子：
7
作者：
Howe, KL;Chothia, T;Durbin, R
通讯作者：
Durbin, R
影响因子：
64.8
作者：
Aury, Jean-Marc;Jaillon, Olivier;Wincker, Patrick
通讯作者：
Wincker, Patrick