Neuronal Regulation of Cutaneous Immunity.

Neuronal Regulation of Cutaneous Immunity.
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DOI:
10.4049/jimmunol.1901109
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发表时间:
2020-01-15
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
通讯作者:
Kaplan DH
Kaplan DH
中科院分区:
其他
文献类型:
--
作者:
Cohen JA;Wu J;Kaplan DH

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皮肤由许多感觉传入神经元支配,这些神经元对各种各样的刺激做出反应,从轻柔的触摸到剧痛。免疫系统的各种特征-病原体识别,可溶性介质的分泌-与神经系统共享。这导致人们认识到神经元与先天免疫细胞共享某些功能,并具有识别病原体和参与先天免疫反应的能力。神经免疫相互作用是双向的。来自免疫细胞的可溶性介质激活神经元,来自神经元的可溶性介质激活免疫细胞。在这篇综述中,我们将重点讨论在宿主防御和炎症的背景下,神经元与皮肤先天免疫之间的相互作用。
The skin is innervated by numerous sensory afferent neurons that respond to a diverse array of stimuli ranging from gentle touch to noxious pain. Various features of the immune system—pathogen recognition, secretion of soluble mediators—are shared with the nervous system. This has led to the recognition that neurons share some functions with innate immune cells and have the capacity to recognize pathogens and participate in innate immune responses. Neuroimmune interactions are bidirectional. Soluble mediators from immune cells activate neurons and soluble mediators from neurons can activate immune cells. In this review, we will focus on the interplay between neurons and innate immunity in the skin in the context of host defense and inflammation.
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