Glial Patchwork: Oligodendrocyte Progenitor Cells and Astrocytes Blanket the Central Nervous System.
Glial Patchwork: Oligodendrocyte Progenitor Cells and Astrocytes Blanket the Central Nervous System.
复制标题
DOI：
10.3389/fncel.2021.803057
复制
发表时间：
2021
影响因子：
5.3
通讯作者：
Kucenas S
中科院分区：
文献类型：
--
作者：
Barber HM;Ali MF;Kucenas S
平铺是细胞群均匀分布在整个组织中的发育过程。本文就中枢神经系统（CNS）中两种主要的胶质细胞群--少突胶质细胞祖细胞（OPCs）和星形胶质细胞的发育细胞贴壁行为进行综述。首先，我们讨论了OPC平铺在脊髓，这是由三个细胞的迁移，增殖和接触介导的排斥（CMR）的行为。这些细胞行为在OPC发育过程中同时发生，并会聚以产生平铺的紧急行为，这导致OPC均匀分散并占据整个CNS的非重叠结构域。我们接下来讨论星形胶质细胞在皮层和海马中的平铺，星形胶质细胞在那里迁移、增殖，然后通过逐渐去除重叠而不是持续的CMR来最终确定它们的专属域。这导致结构域略微重叠，允许“突触岛”和星形胶质细胞-星形胶质细胞通信的排他性控制。最后，我们讨论了这些胶质细胞群体的平铺行为的相似性和差异，以及胶质细胞平铺的未知情况，以及这一过程的扰动如何影响损伤和疾病。
Tiling is a developmental process where cell populations become evenly distributed throughout a tissue. In this review, we discuss the developmental cellular tiling behaviors of the two major glial populations in the central nervous system (CNS)—oligodendrocyte progenitor cells (OPCs) and astrocytes. First, we discuss OPC tiling in the spinal cord, which is comprised of the three cellular behaviors of migration, proliferation, and contact-mediated repulsion (CMR). These cellular behaviors occur simultaneously during OPC development and converge to produce the emergent behavior of tiling which results in OPCs being evenly dispersed and occupying non-overlapping domains throughout the CNS. We next discuss astrocyte tiling in the cortex and hippocampus, where astrocytes migrate, proliferate, then ultimately determine their exclusive domains by gradual removal of overlap rather than sustained CMR. This results in domains that slightly overlap, allowing for both exclusive control of “synaptic islands” and astrocyte-astrocyte communication. We finally discuss the similarities and differences in the tiling behaviors of these glial populations and what remains unknown regarding glial tiling and how perturbations to this process may impact injury and disease.
登录
查看更多内容
影响因子：
25
作者：
Chen J;Poskanzer KE;Freeman MR;Monk KR
通讯作者：
Monk KR
脑可塑性，稳态和精神疾病中的少突胶质细胞。
影响因子：
5.7
作者：
Birey F;Kokkosis AG;Aguirre A
通讯作者：
Aguirre A
DOI：
10.1093/g3journal/jkab265
发表时间：
2021-09-27
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Ali MF;Latimer AJ;Wang Y;Hogenmiller L;Fontenas L;Isabella AJ;Moens CB;Yu G;Kucenas S
通讯作者：
Kucenas S
影响因子：
8.8
作者：
Chen, Ting-Jiun;Kula, Bartosz;Kukley, Maria
通讯作者：
Kukley, Maria
影响因子：
16.6
作者：
Batiuk, Mykhailo Y.;Martirosyan, Araks;Holt, Matthew G.
通讯作者：
Holt, Matthew G.