Early life adversity and depressive symptoms predict cortisol in pregnancy.
Early life adversity and depressive symptoms predict cortisol in pregnancy.
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DOI：
10.1007/s00737-019-00983-3
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Pullen CH
中科院分区：
文献类型：
--
作者：
Epstein CM;Houfek JF;Rice MJ;Weiss SJ;French JA;Kupzyk KA;Hammer SJ;Pullen CH
有证据表明，早期生活逆境（ELA）会影响下丘脑-垂体-肾上腺（HPA）轴，从而影响女性对后来的逆境的反应，并使她们容易患抑郁症。然而，很少有研究调查ELA是否调节HPA皮质醇对孕妇成年逆境和抑郁症状的反应。本研究的目的是确定(a) ELA、成年逆境和抑郁症状是否对皮质醇模式有差异预测，以及(b) ELA是否调节成年逆境或抑郁症状与皮质醇的关系。这是一项对孕妇（N = 58，平均妊娠26.5周）的描述性横断面研究。参与者完成应激逆境量表和爱丁堡抑郁量表，每天收集唾液皮质醇5次，持续3天，以评估皮质醇觉醒反应（CAR）、皮质醇日斜率和皮质醇曲线下面积（AUC）。ELA预测较大的CAR，而抑郁症状预测钝化的CAR和较高的皮质醇AUC。成年期逆境预示着CAR变钝和更陡的日斜率，但仅适用于ELA高的女性。ELA还能减缓抑郁症状对日斜率的影响。早期逆境和抑郁症状对妊娠期HPA轴有显著影响，早期逆境对抑郁症状和成年逆境对皮质醇调节也有调节作用。早期逆境可能是确定妊娠期HPA表型和HPA轴失调风险的重要因素。
Evidence suggests that exposure to early life adversity (ELA) programs the hypothalamic-pituitary-adrenal (HPA) axis to influence responses to later adversity and predisposes women to depression. However, few studies have examined whether ELA moderates the HPA cortisol response to adulthood adversity and depressive symptoms in pregnant women. The aims of this study were to determine (a) whether ELA, adulthood adversity, and depressive symptoms differentially predict patterns of cortisol and (b) whether ELA moderates the relationship of adulthood adversity or depressive symptoms to cortisol. This was a descriptive, cross-sectional study of pregnant women (N = 58, mean = 26.5 weeks gestation). Participants completed the Stress and Adversity Inventory and Edinburgh Depression Scale and collected salivary cortisol five times per day for 3 days to assess cortisol awakening response (CAR), diurnal cortisol slope, and cortisol area under the curve (AUC). ELA predicted a larger CAR, while depressive symptoms predicted a blunted CAR and higher cortisol AUC. Adulthood adversity predicted a blunted CAR and steeper diurnal slope, but only in women with high ELA. ELA also moderated the effect of depressive symptoms on diurnal slope. Early adversity and depressive symptoms appear to have significant effects on the HPA axis during pregnancy, with early adversity also moderating effects of depressive symptoms and adulthood adversity on cortisol regulation. Early adversity may be an important factor in identifying unique HPA phenotypes and risk for HPA axis dysregulation in pregnancy.
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DOI：
10.1007/s00737-017-0777-y
发表时间：
2018-03
期刊：
Archives of women's mental health
影响因子：
--
作者：
Orta OR;Gelaye B;Bain PA;Williams MA
通讯作者：
Williams MA
影响因子：
17.7
作者：
Nanni, Valentina;Uher, Rudolf;Danese, Andrea
通讯作者：
Danese, Andrea
影响因子：
3.7
作者：
Pruessner, JC;Kirschbaum, C;Hellhammer, DH
通讯作者：
Hellhammer, DH
影响因子：
15.1
作者：
Miller, Gregory E.;Culhane, Jennifer;Borders, Ann
通讯作者：
Borders, Ann
影响因子：
3.7
作者：
Hsiao, Fei-Hsiu;Yang, Tsung-Tsair;Wang, Kuo-Chang
通讯作者：
Wang, Kuo-Chang