Amino acid modified [70] fullerene derivatives with high radical scavenging activity as promising bodyguards for chemotherapy protection.
Amino acid modified [70] fullerene derivatives with high radical scavenging activity as promising bodyguards for chemotherapy protection.
复制标题
DOI：
10.1038/s41598-018-34967-7
复制
发表时间：
2018-11-08
影响因子：
4.6
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Zhou Y;Zhen M;Guan M;Yu T;Ma L;Li W;Zheng J;Shu C;Wang C
尽管近几十年来人们在肿瘤治疗方面做出了巨大的努力，但目前化疗引起的毒性仍然是困扰癌症患者的一个难题，由于严重的副作用，通常会阻碍癌症治疗的顺利完成。一般来说，化疗药物的主要副作用来自于产生的活性氧（ROS），它不仅伤害肿瘤细胞，而且损害患者的器官。本文报道了富勒烯氨基酸衍生物（AADF）在化疗中的应用，它能强烈清除过量的活性氧，保护实验鼠免受化疗引起的肝毒性和心脏毒性。分别用l -赖氨酸和β-丙氨酸两种氨基酸对C70富勒烯进行化学修饰，发现l -赖氨酸衍生物（C70- lys）比β-丙氨酸衍生物（C70- ala）具有更强的自由基清除能力。正如预期的那样，C70-Lys在体内对化疗损伤的保护作用比C70-Ala好得多，这一点得到了各种组织病理学、血液学检查和抗氧化酶研究的证实。l -谷胱甘肽水平升高，细胞色素P-450 2E1表达受到抑制。它们有潜力发展成为化疗保护的有前途的保镖。
Despite the great efforts for tumor therapy in the last decades, currently chemotherapy induced toxicity remains a formidable problem for cancer patients, and it usually prohibits the cancer therapy from successful completion due to severe side effects. In general, the main side effects of chemotherapeutic agents are from the as-produced reactive oxygen species (ROS) that not only harm the tumor cells but also damage the patients’ organs. Here we report the application of amino acid derivatives of fullerene (AADF) in the chemotherapy which strongly scavenge the excess ROS to protect the tested mice against the chemotherapy-induced hepatotoxicity and cardiotoxicity. Two amino acids, i.e., L-lysine and β-alanine were separately employed to chemically modify C70 fullerene, and L-lysine derivative of fullerene (C70-Lys) exhibits superior radical scavenging activity to β-alanine derivative of C70 (C70-Ala). As expected, C70-Lys show much better protective effect than C70-Ala against the chemotherapy injuries in vivo, which is verified by various histopathological, haematological examinations and antioxidative enzyme studies. Moreover, the L-glutathione level is increased and the cytochrome P-450 2E1 expression is inhibited. They are potentially developed as promising bodyguards for chemotherapy protection.
登录
查看更多内容
影响因子：
2.8
作者：
Injac, Rade;Perse, Martina;Strukej, Borut
通讯作者：
Strukej, Borut
影响因子：
3.8
作者：
Iohara, Daisuke;Umezaki, Yoshitaka;Hirayama, Fumitoshi
通讯作者：
Hirayama, Fumitoshi
影响因子：
14
作者：
Injac, Rade;Perse, Martina;Strukelj, Borut
通讯作者：
Strukelj, Borut
杨梅素可防止过氧亚硝酸盐介导的 DNA 损伤和羟基自由基的形成
影响因子：
4.3
作者：
Chen, Wei;Li, Yudong;Li, Ang
通讯作者：
Li, Ang
Gd@C-82-(乙二胺)(8)纳米颗粒：一种新型高效水溶性ROS清除剂
影响因子：
9.5
作者：
Li, Jie;Guan, Mirong;Wang, Chunru
通讯作者：
Wang, Chunru