High-Impact Mechanical Loading Increases Bone Material Strength in Postmenopausal Women-A 3-Month Intervention Study.
High-Impact Mechanical Loading Increases Bone Material Strength in Postmenopausal Women-A 3-Month Intervention Study.
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DOI：
10.1002/jbmr.3431
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Lorentzon M
中科院分区：
文献类型：
--
作者：
Sundh D;Nilsson M;Zoulakis M;Pasco C;Yilmaz M;Kazakia GJ;Hellgren M;Lorentzon M
骨骼以几种方式适应负荷，包括重新分配骨量和改变几何和微结构。由于以往方法学的限制，目前尚不清楚机械载荷对人体骨材料强度的影响。本研究的目的是调查为期3个月的单侧高冲击性运动计划对健康绝经后妇女骨材料特性和微结构的影响。选择20名健康、不活跃的绝经后妇女，年龄55.6 ± 2.3岁[平均 ± SD]，3个月内每天进行单腿跳跃锻炼，每次递增3×10~4×20次。所有参与者都被要求将他们表演的跳跃记录在有组织的每日日记中。参与者选择一条腿作为干预腿，另一条腿作为对照。操作员被蒙在鼓里，不知道参与者选择进行干预的腿。预先确定的主要结果是用手持参考探头压痕仪(OsteoProbe)在胫骨中段测量骨材料强度指数(BMSi)的变化。使用高分辨率外周定量计算机断层扫描(XtremeCT)测量胫骨超远端和胫骨长度的14%处(远端)的骨显微结构、几何形状和密度。差异分析采用相关样本的Wilcoxon符号秩次检验。跳跃计划的总体依从率为93.6%。与对照腿相比，干预腿的骨密度增加了7%或0.89SD(p = 0.046)，但XtremeCT衍生的骨参数没有发现任何差异。综上所述，单侧高冲击加载方案在不影响骨显微结构、几何形状或密度的情况下迅速增加绝经后妇女的BMSI，表明高强度机械加载能够在骨量或结构改变之前迅速改善骨材料特性。©2018作者。《骨与矿物研究杂志》，由威利期刊公司出版。
Bone adapts to loading in several ways, including redistributing bone mass and altered geometry and microarchitecture. Because of previous methodological limitations, it is not known how the bone material strength is affected by mechanical loading in humans. The aim of this study was to investigate the effect of a 3‐month unilateral high‐impact exercise program on bone material properties and microarchitecture in healthy postmenopausal women. A total of 20 healthy and inactive postmenopausal women (aged 55.6 ± 2.3 years [mean ± SD]) were included and asked to perform an exercise program of daily one‐legged jumps (with incremental number, from 3×10 to 4×20 jumps/d) during 3 months. All participants were asked to register their performed jumps in a structured daily diary. The participants chose one leg as the intervention leg and the other leg was used as control. The operators were blinded to the participant's choice of leg for intervention. The predefined primary outcome was change in bone material strength index (BMSi), measured at the mid tibia with a handheld reference probe indentation instrument (OsteoProbe). Bone microstructure, geometry, and density were measured with high‐resolution peripheral quantitative computed tomography (XtremeCT) at the ultradistal and at 14% of the tibia bone length (distal). Differences were analyzed by related samples Wilcoxon signed rank test. The overall compliance to the jumping program was 93.6%. Relative to the control leg, BMSi of the intervention leg increased 7% or 0.89 SD (p = 0.046), but no differences were found for any of the XtremeCT‐derived bone parameters. In conclusion, a unilateral high‐impact loading program increased BMSi in postmenopausal women rapidly without affecting bone microstructure, geometry, or density, indicating that intense mechanical loading has the ability to rapidly improve bone material properties before changes in bone mass or structure. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.
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