Narcolepsy and excessive daytime sleepiness
Narcolepsy and excessive daytime sleepiness
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发作性睡病和白天过度嗜睡
DOI：
10.1136/bmj.329.7468.724
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Z. Zaiwalla
中科院分区：
文献类型：
--
作者：
A. Zeman;T. Britton;Neil J. Douglas;Andrew Hansen;J. Hicks;Robin S. Howard;Andrew Meredith;I. Smith;G. Stores;Sue Wilson;Z. Zaiwalla
过度的白天嗜睡是常见的，1但机会学习睡眠医学在医学院是罕见的; 1998年的一项调查表明，本科课程的中位数为5分钟的睡眠和其disorders.2在这篇综述中，我们提供了一个更新的生物学，诊断和管理嗜睡的一个重要的，但往往误诊，嗜睡的原因，已经看到了令人兴奋的最新进展。我们还简要地概述了其他主要原因的白天嗜睡，并旨在装备一般读者与实用的方法来评估病人抱怨白天过度嗜睡。
本文基于文献检索，旨在为成人和儿童发作性睡病的诊断和管理提供循证指南。3我们检索了Medline、Embase、科克伦协作网和两个专家睡眠文献资源，以获取关键词为“发作性睡病”的摘要。我们阅读了相关论文的全文，并手动搜索了其他相关材料。一个多学科工作组编写了这些准则，一个由10名独立专家组成的小组随后对准则进行了审查。这些准则可从http://www.sleeping.org.uk/（2004年7月访问）的新闻部分下载。
发作性睡病是一种慢性神经系统疾病，影响睡眠调节，并导致过度嗜睡，在大多数情况下，会导致昏厥（情绪激动时短暂的虚弱发作）。这种欲望在有益的、单调的环境下会更强烈，但在不合适的时间小睡，比如吃饭时，是一种特征。嗜睡症的小睡通常持续几分钟到一个小时，每天发生几次。Cataillation指的是部分或全身性的，几乎总是双侧的，骨骼肌张力的丧失和...
Excessive daytime sleepiness is common,1 yet opportunities to learn about sleep medicine in medical school are rare; a survey in 1998 indicated that undergraduate courses devoted a median of five minutes to sleep and its disorders.2 In this review we provide an update on the biology, diagnosis, and management of narcolepsy—an important, yet often misdiagnosed, cause of sleepiness that has seen exciting recent advances. We also briefly outline the other principal causes of daytime sleepiness and aim to equip the general reader with a practical approach to the assessment of patients who complain of excessive daytime sleepiness.
This paper is based on a literature search conducted to produce evidence based guidelines on the diagnosis and management of narcolepsy in adults and children.3 We searched Medline, Embase, the Cochrane Collaboration, and two specialist sleep literature resources for abstracts with the key word “narcolepsy.” We read the full text of relevant papers and hand searched these for other relevant material. A multidisciplinary working party prepared the guidelines, and a group of 10 independent experts later reviewed them. These guidelines can be downloaded from the news section of http://www.sleeping.org.uk/ (accessed July 2004).
Narcolepsy is a chronic neurological disorder affecting sleep regulation and causing excessive sleepiness and, in most cases, cataplexy (brief attacks of weakness on emotional arousal).3 4 The excessive sleepiness of narcolepsy comprises both a background feeling of sleepiness present much of the time and a strong, sometime irresistible, urge to sleep recurring at intervals through the day. This desire is heightened by conducive, monotonous circumstances, but naps at inappropriate times—such as during meals—are characteristic. The naps of narcolepsy usually last from minutes to an hour and occur a few times each day. Cataplexy refers to partial or generalised, almost invariably bilateral, loss of skeletal muscle tone and …
DOI：
10.1073/pnas.95.1.322
发表时间：
1998-01-06
影响因子：
11.1
作者：
De Lecea, L;Kilduff, TS;Sutcliffe, JG
通讯作者：
Sutcliffe, JG
影响因子：
--
作者：
Mignot, E;Lammers, GJ;Nishino, S
通讯作者：
Nishino, S
HLA DQB1*0602 与 509 名发作性睡病患者的猝倒相关。
影响因子：
5.6
作者：
Mignot,E;Hayduk,R;Black,J;Grumet,FC;Guilleminault,C
通讯作者：
Guilleminault,C