Brain lateralization in children with upper-limb reduction deficiency.
Brain lateralization in children with upper-limb reduction deficiency.
复制标题
上LIMB降低缺乏症儿童的大脑横向化。
DOI：
10.1186/s12984-020-00803-1
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发表时间：
2021-02-03
影响因子：
5.1
通讯作者：
Huppert T
中科院分区：
文献类型：
--
作者：
Zuniga JM;Pierce JE;Copeland C;Cortes-Reyes C;Salazar D;Wang Y;Arun KM;Huppert T
本研究的目的是确定与正常发育儿童（TD）相比，先天性单侧上肢复位缺陷（ULD）儿童上肢假肢对大脑活动和总体灵活性的影响。5名ULD儿童（3名男孩，2名女孩，8.76 ± 3.37岁）和5名年龄和性别匹配的TD儿童（3名男孩，2名女孩，8.96 ± 3.23岁）在测量大脑活动（功能性近红外光谱; fNIRS）的同时进行了粗略的手动灵巧性任务（方块和方块测试）。使用假体的ULD组（7.23 ± 3.37块/分钟）和使用假体模拟器的TD组（7.63 ± 5.61块/分钟）之间的总体灵巧性表现无显著差异（p = 0.948）。然而，带假体的ULD组（LI = − 0.2888 ± 0.0205）和带模拟器的TD组（LI = 0.0504 ± 0.0296）之间的偏侧指数（LI）存在显著差异（p = 0.001），表明ULD组的同侧对照具有显著性。因此，本研究的主要发现是，与对照组不同，ULD儿童在使用假体进行粗手动灵巧性任务时，在非首选侧的同侧运动皮层中显示出显著的激活。这种同侧反应可能是一种补偿策略，其中受影响（非首选）侧使用非受影响（首选）侧的现有皮质表示来操作假体。这项研究是第一个报告改变偏侧的儿童ULD，而使用假体。临床试验（ClinicalTrial.gov ID：NCT 04110730和唯一方案ID：IRB # 614-16-FB）于2019年10月1日注册（https：//clinicaltrials.gov/ct2/show/NCT04110730），并于2019年10月1日发布。研究开始日期为2020年1月10日。第一名受试者于2020年1月14日入组，试验计划于2023年8月23日完成。该试验于2020年1月18日更新，目前正在招募
The purpose of the current study was to determine the influence of upper-limb prostheses on brain activity and gross dexterity in children with congenital unilateral upper-limb reduction deficiencies (ULD) compared to typically developing children (TD). Five children with ULD (3 boys, 2 girls, 8.76 ± 3.37 years of age) and five age- and sex-matched TD children (3 boys, 2 girls, 8.96 ± 3.23 years of age) performed a gross manual dexterity task (Box and Block Test) while measuring brain activity (functional near-infrared spectroscopy; fNIRS). There were no significant differences (p = 0.948) in gross dexterity performance between the ULD group with prosthesis (7.23 ± 3.37 blocks per minute) and TD group with the prosthetic simulator (7.63 ± 5.61 blocks per minute). However, there was a significant (p = 0.001) difference in Laterality Index (LI) between the ULD group with prosthesis (LI = − 0.2888 ± 0.0205) and TD group with simulator (LI = 0.0504 ± 0.0296) showing in a significant ipsilateral control for the ULD group. Thus, the major finding of the present investigation was that children with ULD, unlike the control group, showed significant activation in the ipsilateral motor cortex on the non-preferred side using a prosthesis during a gross manual dexterity task. This ipsilateral response may be a compensation strategy in which the existing cortical representations of the non-affected (preferred) side are been used by the affected (non-preferred) side to operate the prosthesis. This study is the first to report altered lateralization in children with ULD while using a prosthesis. Trial registration The clinical trial (ClinicalTrial.gov ID: NCT04110730 and unique protocol ID: IRB # 614-16-FB) was registered on October 1, 2019 (https://clinicaltrials.gov/ct2/show/NCT04110730) and posted on October 1, 2019. The study start date was January 10, 2020. The first participant was enrolled on January 14, 2020, and the trial is scheduled to be completed by August 23, 2023. The trial was updated January 18, 2020 and is currently recruiting
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影响因子：
1.7
作者：
Hamzei, F;Liepert, J;Weiller, C
通讯作者：
Weiller, C
影响因子：
1.5
作者：
Biddiss, Elaine A.;Chau, Tom T.
通讯作者：
Chau, Tom T.
影响因子：
1.5
作者：
Huizing, Karin;Reinders-Messelink, Heleen;van der Sluis, Corry K.
通讯作者：
van der Sluis, Corry K.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.9
作者：
MATHIOWETZ, V;VOLLAND, G;WEBER, K
通讯作者：
WEBER, K