High weight loss during radiation treatment changes the prognosis in under-/normal weight nasopharyngeal carcinoma patients for the worse: a retrospective analysis of 2433 cases.
High weight loss during radiation treatment changes the prognosis in under-/normal weight nasopharyngeal carcinoma patients for the worse: a retrospective analysis of 2433 cases.
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放射治疗期间的体重大幅下降使体重不足/正常的鼻咽癌患者的预后变得更糟：对 2433 例病例的回顾性分析。
DOI：
10.1371/journal.pone.0068660
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Xia YF
中科院分区：
文献类型：
--
作者：
Shen LJ;Chen C;Li BF;Gao J;Xia YF
虽然体重减轻在接受放射治疗的鼻咽癌(NPC)患者中很常见，但体重减轻对预后的影响以及体重指数(BMI)修正后的影响仍不清楚。纳入2000-11/2004-12在中山大学肿瘤中心接受根治性放疗的鼻咽癌患者2433例。放射治疗期间的体重变化分为高体重下降(HWL)和低体重下降(LWL)。用Cox回归分析HWL与总生存期(OS)和疾病特异性生存期(DSS)的关系。在体重不足的患者中，与LWL相比，与LWL相比，HWL独立地与OS(危险比[HR]，2.06；95%可信区间1.36-3.11)和DSS(HR，2.27；95%可信区间1.38-3.73)相关。在正常体重患者中，HWL对OS(HR，1.47；95%CI 1.19-1.80)和DSS(HR，1.59；95%CI 1.24-2.03)的影响为中等。在超重/肥胖患者中，未发现HWL与OS(HR，1.22；95%CI 0.95-1.55)或DSS(HR，1.23；95%CI 0.93-1.64)显著相关。除超重/肥胖患者外，放疗期间体重减轻程度高与鼻咽癌患者的存活率低独立相关。这一影响在体重不足的患者组中更为突出。
Although weight loss is common in nasopharyngeal carcinoma (NPC) patients receiving radiotherapy, the prognostic influence of weight loss and its impact modified by body mass index (BMI) are still unclear. 2433 NPC patients receiving radical radiotherapy at Sun Yat-sen University Cancer Center from November, 2000 to December, 2004 were enrolled. Weight change during radiation treatment was categorized into high weight loss (HWL) and low weight loss (LWL). The associations of HWL with overall survival (OS) and disease-specific survival (DSS) were analyzed by Cox regression. Among underweight patients, HWL was independently associated with poor OS (hazard ratio [HR], 2.06; 95% CI 1.36–3.11) and DSS (HR, 2.27; 95% CI 1.38–3.73), as compared with LWL, after adjusting for covariates. In normal weight patients, the impact of HWL on OS (HR, 1.47; 95% CI 1.19–1.80) and DSS (HR, 1.59; 95% CI 1.24–2.03) was moderate. Among overweight/obese patients, no significant association between HWL and OS (HR, 1.22; 95% CI 0.95–1.55), or DSS (HR, 1.23; 95% CI 0.93–1.64) was found. Except for overweight/obese patients, high weight loss during radiation treatment was independently associated with poor survival in NPC. This impact was more prominent in the underweight patient group.
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治疗前体重指数作为局部晚期鼻咽癌放化疗患者的独立预后因素：随机试验的结果
影响因子：
8.4
作者：
Huang, Pei-Yu;Wang, Cheng-Tao;Hong, Ming-Huang
通讯作者：
Hong, Ming-Huang
影响因子：
45.3
作者：
Fang, Fu-Min;Tsai, Wen-Ling;Lee, Chien-Hung
通讯作者：
Lee, Chien-Hung
DOI：
10.1177/0115426502017004246
发表时间：
2002-08-01
期刊：
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
影响因子：
--
作者：
Canada, Todd
通讯作者：
Canada, Todd
影响因子：
5.7
作者：
Ghadjar, Pirus;Simcock, Mathew;Aebersold, Daniel M.
通讯作者：
Aebersold, Daniel M.
影响因子：
6.2
作者：
Nourissat, Alice;Bairati, Isabelle;Meyer, Francois
通讯作者：
Meyer, Francois