Improving External Validity of Epidemiologic Cohort Analyses: A Kernel Weighting Approach.
Improving External Validity of Epidemiologic Cohort Analyses: A Kernel Weighting Approach.
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DOI:
10.1111/rssa.12564
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发表时间:
2020-06
期刊:
影响因子:
--
通讯作者:
Li Y
中科院分区:
文献类型:
--
作者:
Wang L;Graubard BI;Katki HA;Li Y
For various reasons, cohort studies generally forgo probability sampling required to obtain population representative samples. However, such cohorts lack population-representativeness, which invalidates estimates of population prevalences for novel health factors only available in cohorts. To improve external validity of estimates from cohorts, we propose a kernel weighting (KW) approach that uses survey data as a reference to create pseudo-weights for cohorts. A jackknife variance is proposed for the KW estimates. In simulations, the KW method outperformed two existing propensity-score-based weighting methods in mean-squared error while maintaining confidence interval coverage. We applied all methods to estimating US population mortality and prevalences of various diseases from the non-representative US NIH-AARP cohort, using the sample from US-representative National Health Interview Survey (NHIS) as the reference. Assuming that the NHIS estimates are correct, the KW approach yielded generally less biased estimates compared to the existing propensity-score-based weighting methods.
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DOI:
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