Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles
Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles
复制标题
微泡壳化学对超声造影剂微泡破坏阈值的影响
DOI：
10.1007/978-94-007-2619-2_10
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
G. Schmitz
中科院分区：
文献类型：
--
作者：
M. Mleczko;S. Dicker;S. Wrenn;G. Schmitz
超声造影剂的破坏阈值是靶向药物输送的安全性和应用的重要参数。由于该阈值是脂质壳微泡的化学成分的函数，因此调整该成分可以允许调整破坏阈值。为了实现这一目标，本研究提出了一个分析破坏阈值的框架。提出了一种从理论上确定该阈值的方法。随后通过实验验证理论结果，得出壳粘度和弹性与 DSPE-PEG2000 浓度之间的线性相关性。
The destruction threshold of ultrasound contrast agents is an important parameter for safety and applications in targeted drug delivery. Since this threshold is a function of the chemical composition of lipid-shelled microbubbles, adjustment of this composition may allow tuning of the destruction threshold. To attain this goal, this study presents a framework for the analysis of the destruction threshold. A method for the theoretical determination of this threshold is presented. Theoretical results are subsequently validated by experiments, yielding a linear dependence between shell viscosity and elasticity and DSPE-PEG2000 concentration.
影响因子：
2.9
作者：
APFEL, RE;HOLLAND, CK
通讯作者：
HOLLAND, CK