Regional and duration of illness differences in the alteration of NCAM-180 mRNA expression within the cortex of subjects with schizophrenia.
Regional and duration of illness differences in the alteration of NCAM-180 mRNA expression within the cortex of subjects with schizophrenia.
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DOI：
10.1016/j.schres.2009.04.002
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发表时间：
2009-07
影响因子：
4.5
通讯作者：
Dean, B.
中科院分区：
文献类型：
--
作者：
Gibbons, A. S.;Thomas, E. A.;Dean, B.
Schizophrenia has been proposed to have a neurodevelopmental aetiology. Neural Cell Adhesion Molecule 1 (NCAM1) is involved in several neurodevelopmental processes and abnormal expression of this gene has been associated in the pathology of schizophrenia and, thus, altered NCAM1 expression may be characteristic of the early stages of the illness. Alternative splicing of the NCAM1 transcript produces 3 major isoforms. Using qPCR we analysed mRNA expression of one of these isoforms; the 180 kDa isoform of NCAM1 (NCAM-180), in Brodmann Area (BA) 46, BA10 and BA17, postmortem, from 15 subjects with a short duration of illness of schizophrenia (<7 years) and 15 control subjects. NCAM-180 mRNA expression was increased in BA46 from subjects with schizophrenia compared to controls (P=0.013). By contrast, there were no significant differences in the expression of NCAM-180 mRNA in BA10 (P=0.575) or BA17 (P=0.772). We then analysed NCAM-180 mRNA expression in BA46 from 15 subjects with a longer duration of illness of schizophrenia (>22 years) and 15 controls. There was no significant difference in NCAM-180 mRNA expression in this second cohort. This data suggests NCAM-180 mRNA expression is altered in a regionally-specific manner in schizophrenia and these changes are associated with the early period following diagnosis.
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DOI：
10.1083/jcb.200303020
发表时间：
2003-05-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Leshchyns'ka I;Sytnyk V;Morrow JS;Schachner M
通讯作者：
Schachner M
DOI：
10.1016/0169-328x(94)00219-5
发表时间：
1995-02-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
KINGSBURY, AE;FOSTER, OJF;MARSDEN, CD
通讯作者：
MARSDEN, CD
影响因子：
3.3
作者：
Honer, WG;Falkai, P;Trimble, WS
通讯作者：
Trimble, WS
影响因子：
5.6
作者：
Mackowiak, Marzena;Dudys, Dorotal;Wedzony, Krzysztof
通讯作者：
Wedzony, Krzysztof
影响因子：
11.4
作者：
HE, HT;BARBET, J;GORIDIS, C
通讯作者：
GORIDIS, C