Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine.
Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine.
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DOI：
10.1016/j.tips.2009.10.003
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发表时间：
2010-01
影响因子：
13.8
通讯作者：
Quirk GJ
中科院分区：
文献类型：
--
作者：
Holmes A;Quirk GJ
目前人们对识别有助于消除恐惧的药物感兴趣，因为这种形式的学习是某些焦虑症认知疗法的基础。几年前的初步报告称α2-肾上腺素受体拮抗剂育亨宾会促进小鼠的灭绝，最近的研究显示出混合效应甚至损害。很明显，育亨宾对灭绝的影响取决于许多因素，包括遗传背景、背景变量和竞争行为的存在。与其他作用位点相反，育亨宾的这些作用在多大程度上是通过 α2-肾上腺素受体介导的，目前还不确定。在这种药物被批准作为基于灭绝的疗法的药理学辅助剂之前，还需要做更多的工作。更一般地说，育亨宾的例子可以作为开发其他灭绝促进剂的模型。
There is current interest in identifying drugs that facilitate fear extinction, as this form of learning is the basis of certain cognitive therapies for anxiety disorders. Following an initial report several years ago that the α2-adrenoreceptor antagonist yohimbine facilitated extinction in mice, more recent studies have shown mixed effects or even impairment. It has become clear that the effect of yohimbine on extinction depends on a number of factors, including genetic background, contextual variables and the presence of competing behaviors. To what extent theses effects of yohimbine are mediated through the α2-adrenoreceptor, as opposed to other sites of action, is also uncertain. More work is needed before this drug can be approved as a pharmacological adjunct for extinction-based therapies. More generally, the case of yohimbine may serve as a model for the development of other extinction facilitators.
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DOI：
10.1523/jneurosci.4904-07.2008
发表时间：
2008-08-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hefner K;Whittle N;Juhasz J;Norcross M;Karlsson RM;Saksida LM;Bussey TJ;Singewald N;Holmes A
通讯作者：
Holmes A
DOI：
10.1037/0097-7403.29.4.323
发表时间：
2003-10-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
Cain, CK;Blouin, AM;Barad, M
通讯作者：
Barad, M
影响因子：
10.6
作者：
Davis, Michael;Ressler, Kerry;Richardson, Rick
通讯作者：
Richardson, Rick
影响因子：
10.6
作者：
Burghardt, Nesha S.;Bush, David E. A.;LeDoux, Joseph E.
通讯作者：
LeDoux, Joseph E.
影响因子：
4.7
作者：
Becker, C;Hamon, M;Benoliel, JJ
通讯作者：
Benoliel, JJ