Rapid evolutionary response to a transmissible cancer in Tasmanian devils.
Rapid evolutionary response to a transmissible cancer in Tasmanian devils.
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DOI：
10.1038/ncomms12684
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发表时间：
2016-08-30
影响因子：
16.6
通讯作者：
Storfer, Andrew
中科院分区：
文献类型：
--
作者：
Epstein, Brendan;Jones, Menna;Hamede, Rodrigo;Hendricks, Sarah;McCallum, Hamish;Murchison, Elizabeth P.;Schonfeld, Barbara;Wiench, Cody;Hohenlohe, Paul;Storfer, Andrew
虽然癌症很少作为传染病，但最近在袋獾（Sarcophilus harrisii）中出现的一种传染性癌症几乎是100%致命的。魔鬼面部肿瘤病（DFTD）几乎席卷了整个物种的范围，导致局部下降超过90%，整体物种在不到20年的时间里下降超过80%。尽管流行病学模型预测灭绝，但长期患病地区的种群仍然存在。在这里，我们报告了罕见的基因组证据，表明对野生动物疾病施加的强选择产生了快速、平行的进化反应。我们确定了两个包含与人类免疫功能或癌症风险相关的基因的基因组区域，它们在三个人群中表现出一致的选择特征。DFTD通过抑制和逃避免疫系统在宿主之间传播，我们的研究结果表明，宿主正在进化免疫调节的抵抗力，这可能有助于物种在面对这种毁灭性疾病时的持久性。最近出现的一种传染性癌症导致袋獾几乎灭绝，但一些种群仍然存在。在这里，Epstein等人通过包含癌症相关免疫反应基因的两个基因组区域的快速进化提供了可能的耐药性证据。
Although cancer rarely acts as an infectious disease, a recently emerged transmissible cancer in Tasmanian devils (Sarcophilus harrisii) is virtually 100% fatal. Devil facial tumour disease (DFTD) has swept across nearly the entire species' range, resulting in localized declines exceeding 90% and an overall species decline of more than 80% in less than 20 years. Despite epidemiological models that predict extinction, populations in long-diseased sites persist. Here we report rare genomic evidence of a rapid, parallel evolutionary response to strong selection imposed by a wildlife disease. We identify two genomic regions that contain genes related to immune function or cancer risk in humans that exhibit concordant signatures of selection across three populations. DFTD spreads between hosts by suppressing and evading the immune system, and our results suggest that hosts are evolving immune-modulated resistance that could aid in species persistence in the face of this devastating disease. A recently emerged infectious cancer has caused the near extinction of the Tasmanian devil, but some populations persist. Here, Epstein et al. provide evidence for possible resistance via rapid evolution in two genomic regions that contain cancer-related immune response genes.
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DOI：
10.1093/bioinformatics/btq033
发表时间：
2010-03-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Quinlan AR;Hall IM
通讯作者：
Hall IM
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
7
作者：
Decker B;Davis BW;Rimbault M;Long AH;Karlins E;Jagannathan V;Reiman R;Parker HG;Drögemüller C;Corneveaux JJ;Chapman ES;Trent JM;Leeb T;Huentelman MJ;Wayne RK;Karyadi DM;Ostrander EA
通讯作者：
Ostrander EA
影响因子：
64.5
作者：
Metzger MJ;Reinisch C;Sherry J;Goff SP
通讯作者：
Goff SP
影响因子：
4.8
作者：
McCallum, Hamish;Jones, Menna;Lazenby, Billie
通讯作者：
Lazenby, Billie