Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams.
Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams.
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DOI：
10.1016/j.cell.2015.02.042
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发表时间：
2015-04-09
期刊：
影响因子：
64.5
通讯作者：
Goff SP
中科院分区：
文献类型：
--
作者：
Metzger MJ;Reinisch C;Sherry J;Goff SP
海洋双壳贝类致命的白血病样癌症在世界各地的爆发导致了大量的人口损失。这种疾病的病因尚不清楚。我们最近发现了一个逆转录转座子，蒸笼，这是高度表达和扩增到高拷贝数的软壳蛤（海蛤）的肿瘤细胞。通过对Steamer整合位点、线粒体DNA单核苷酸多态性（SNP）和多态性微卫星等位基因的分析，我们发现肿瘤细胞的基因型与宿主动物的基因型不匹配。相反，来自纽约、缅因州和加拿大的爱德华王子岛（PEI）的肿瘤细胞都具有与宿主不同的几乎相同的基因型。这些结果表明，癌症是作为来自单个原始蛤蜊的克隆传播细胞在海洋环境中的动物之间传播的。我们的研究结果表明，癌细胞的水平传播在自然界中比以前想象的更广泛。
Outbreaks of fatal leukemia-like cancers of marine bivalves throughout the world have led to massive population loss. The cause of the disease is unknown. We recently identified a retrotransposon, Steamer, that is highly expressed and amplified to high copy number in neoplastic cells of soft-shell clams (Mya arenaria). Through analysis of Steamer integration sites, mitochondrial DNA single nucleotide polymorphisms (SNPs), and polymorphic microsatellite alleles, we show that the genotypes of neoplastic cells do not match those of the host animal. Instead, neoplastic cells from dispersed locations in New York, Maine, and Prince Edward Island (PEI), Canada, all have nearly identical genotypes that differ from those of the host. These results indicate that the cancer is spreading between animals in the marine environment as a clonal transmissible cell derived from a single original clam. Our findings suggest that horizontal transmission of cancer cells is more widespread in nature than previously supposed.
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影响因子：
64.8
作者：
De Tomaso, AW;Nyholm, SV;Weissman, IL
通讯作者：
Weissman, IL
影响因子：
8
作者：
Murchison, E P
通讯作者：
Murchison, E P
影响因子：
4.5
作者：
Beal, BF;Kraus, MG
通讯作者：
Kraus, MG
DOI：
10.1073/pnas.1409945111
发表时间：
2014-09-30
影响因子：
11.1
作者：
Arriagada, Gloria;Metzger, Michael J.;Goff, Stephen P.
通讯作者：
Goff, Stephen P.
影响因子：
3.4
作者：
Delaporte, Maryse;Synard, Stephanie;Berthe, Franck C. J.
通讯作者：
Berthe, Franck C. J.