Gut dysbiosis and age-related neurological diseases in females.
Gut dysbiosis and age-related neurological diseases in females.
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女性的肠道营养不良和与年龄有关的神经疾病。
DOI：
10.1016/j.nbd.2022.105695
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发表时间：
2022-06-15
影响因子：
6.1
通讯作者：
McCullough, Louise D.
中科院分区：
文献类型：
--
作者：
Korf, Janelle M.;Ganesh, Bhanu P.;McCullough, Louise D.
关键词：
从历史上看，女性在生物学研究中的代表性不足。随着对肠道微生物组和肠-脑轴的兴趣增加，研究人员必须将性别视为一个生物变量。肠道微生物组的组成受环境因素，疾病，饮食的影响，并随年龄和性别而变化。肠道微生物组中的有害变化，称为生态失调，被认为影响年龄相关的神经退行性疾病如阿尔茨海默病、帕金森病、亨廷顿病和中风的发展和进展。许多人正在研究微生物种群的变化，以便更好地了解肠道免疫和微生物组在神经退行性疾病中的作用，其中许多疾病的确切病因仍然难以捉摸，并且没有治愈方法。其他人正在努力寻找早期检测的诊断标志物，或使用益生菌治疗性地调节微生物种群。然而，尽管所有这些疾病都存在于生殖衰老的雌性动物中，但大多数研究仅使用雄性动物进行实验设计。生殖性衰老的女性已被证明在疾病进展、炎症反应和微生物群组成方面存在差异，因此，为了使研究转化为受影响的人群，有必要使用适当的模型。这篇综述讨论了影响女性肠道微生物组和肠脑轴的因素，并强调了研究微生态失调在年龄相关的神经退行性疾病中的作用的研究，这些疾病包括女性。
Historically, females have been underrepresented in biological research. With increased interest in the gut microbiome and the gut-brain axis, it is important for researchers to pursue studies that consider sex as a biological variable. The composition of the gut microbiome is influenced by environmental factors, disease, diet, and varies with age and by sex. Detrimental changes in the gut microbiome, referred to as dysbiosis, is believed to influence the development and progression of age-related neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and stroke. Many are investigating the changes in microbial populations in order or to better understand the role of the gut immunity and the microbiome in neurodegenerative diseases, many of which the exact etiology remains elusive, and no cures exist. Others are working to find diagnostic markers for earlier detection, or to therapeutically modulate microbial populations using probiotics. However, while all these diseases present in reproductively senescent females, most studies only use male animals for their experimental design. Reproductively senescent females have been shown to have differences in disease progression, inflammatory responses, and microbiota composition, therefore, for research to be translational to affected populations it is necessary for appropriate models to be used. This review discusses factors that influence the gut microbiome and the gut brain axis in females, and highlights studies that have investigated the role of dysbiosis in age-related neurodegenerative disorders that have included females in their study design.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
老年小鼠缺血性中风后T细胞免疫反应，肠道渗透性和结果的性别差异。
DOI：
10.1016/j.bbi.2020.02.001
发表时间：
2020-07
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Ahnstedt H;Patrizz A;Chauhan A;Roy-O'Reilly M;Furr JW;Spychala MS;D'Aigle J;Blixt FW;Zhu L;Bravo Alegria J;McCullough LD
通讯作者：
McCullough LD
影响因子：
7.7
作者：
Colombo AV;Sadler RK;Llovera G;Singh V;Roth S;Heindl S;Sebastian Monasor L;Verhoeven A;Peters F;Parhizkar S;Kamp F;Gomez de Aguero M;MacPherson AJ;Winkler E;Herms J;Benakis C;Dichgans M;Steiner H;Giera M;Haass C;Tahirovic S;Liesz A
通讯作者：
Liesz A
影响因子：
4.1
作者：
Abraham, Danielle S.;Gruber-Baldini, Ann L.;Shulman, Lisa M.
通讯作者：
Shulman, Lisa M.
影响因子：
5.5
作者：
Carranza-Naval MJ;Vargas-Soria M;Hierro-Bujalance C;Baena-Nieto G;Garcia-Alloza M;Infante-Garcia C;Del Marco A
通讯作者：
Del Marco A