Cerebellar cortex and eyeblink conditioning: bilateral regulation of conditioned responses
Cerebellar cortex and eyeblink conditioning: bilateral regulation of conditioned responses
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小脑皮层和眨眼条件反射：条件反应的双边调节
DOI：
10.1007/bf00231978
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发表时间：
1995
影响因子：
2
通讯作者：
C. Yeo
中科院分区：
文献类型：
--
作者：
A. Gruart;C. Yeo
我们通过比较单侧和双侧小脑皮质损伤的影响，研究了小脑在兔子瞬膜反应（NMR）经典条件反射中的作用。利用术前长时间的条件反射训练以确保高水平的学习，我们证实，小叶HVI和蚓部小叶的单侧损伤会损害先前对听觉条件刺激建立的条件反射（CRs），但不会阻止术后再训练时的一些重新学习。HVI和蚓部小叶的双侧损伤产生了类似的CRs损害，并且还阻止了后续的重新学习。单侧皮质损伤使眶周电刺激的非条件反应（UR）幅度显著增强。双侧皮质损伤在较小程度上增强了UR幅度。由于在单侧和双侧损伤组中，CR损害程度与UR增强之间没有相关性，所以损伤因对行为表现的一般影响而非学习缺失而损害CRs这一观点未得到支持。小脑皮质的两侧都对单侧训练的CR的学习有贡献。这一发现对于重新解释那些发现小脑深部核团不参与NMR条件反射习得的单侧、可逆性失活研究很重要。此外，我们发现非条件反应存在依赖于条件反射的改变，这种改变在眶周电刺激强度较低时尤为明显。这一发现对于重新解释那些在小脑损伤后发现条件反射受试者的UR有明显变化的研究很重要。
We examined the role of the cerebellum in classical conditioning of the nictitating membrane response (NMR) of rabbits by comparing the effects of unilateral and bilateral cerebellar cortical lesions. Using extended preoperative conditioning to ensure high levels of learning, we confirmed that unilateral lesions of lobules HVI and ansiform lobe impaired conditioned responses (CRs) previously established to an auditory conditioned stimulus, but did not prevent some relearning with post-operative retraining. Bilateral lesions of HVI and ansiform lobe produced similar impairments of CRs, but also prevented subsequent relearning. Unilateral cortical lesions produced significant enhancement of unconditioned response (UR) amplitudes to periorbital electrical stimulation. Bilateral cortical lesions enhanced UR amplitudes to a lesser extent. Because there was no correlation between the degree of CR impairment and UR enhancement across the unilateral and bilateral lesion groups, the suggestion that the lesions impaired CRs due to general effects upon performance, rather than due to losses of learning, is not supported. Both sides of the cerebellar cortex contribute towards learning a unilaterally trained CR. This finding is important for the re-interpretation of unilateral, reversible inactivation studies that have found no involvement of the cerebellar deep nuclei in the acquisition of NMR conditioning. In addition, we found conditioning-dependent modifications of unconditioned responses that were particularly apparent at low intensities of periorbital electrical stimulation. This finding is important for the re-interpretation of studies that have found apparent changes in the UR of conditioned subjects after cerebellar lesions.
兔子单侧小脑损伤后学习能力转移但记忆不转移。
影响因子：
1.9
作者：
Lavond,DG;Kanzawa,SA;Ivkovich,D;Clark,RE
通讯作者：
Clark,RE
小脑病变后经典眼睑调节的破坏：记忆痕迹系统受损还是简单的表现缺陷？
DOI：
10.1523/jneurosci.12-11-04403.1992
发表时间：
1992
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Steinmetz,JE;Lavond,DG;Ivkovich,D;Logan,CG;Thompson,RF
通讯作者：
Thompson,RF