Does a lack of vaccine side effects correlate with reduced BNT162b2 mRNA vaccine response among healthcare workers and nursing home residents?
Does a lack of vaccine side effects correlate with reduced BNT162b2 mRNA vaccine response among healthcare workers and nursing home residents?
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DOI：
10.1007/s40520-021-01987-9
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发表时间：
2021-11
影响因子：
4
通讯作者：
Gravenstein S
中科院分区：
文献类型：
--
作者：
Oyebanji OA;Wilson B;Keresztesy D;Carias L;Wilk D;Payne M;Aung H;Denis KS;Lam EC;Rowley CF;Berry SD;Cameron CM;Cameron MJ;Schmader KE;Balazs AB;King CL;Canaday DH;Gravenstein S
BNT 162 b2 SARS-CoV-2 mRNA疫苗接种大大减轻了长期护理机构居民的COVID-19负担，尽管被排除在疫苗试验之外。该人群中的反应原性（疫苗副作用）数据有限。评估护理之家（NH）居民的反应原性。为预测该人群中的疫苗应答提供一个合理的替代。我们招募并采样了接受BNT 162 b2 mRNA疫苗的NH居民和社区居住的医护人员，以评估局部或全身反应原性和抗体水平（免疫原性）。NH居民报告的反应频率要低得多，严重程度低于社区居住的医疗保健工作者。这些反应为轻度和一过性，所有受试者的局部反应多于全身反应。基于我们的反应原性和免疫原性数据，我们开发了一个线性回归模型，预测对数转换的抗刺突、抗受体结合结构域（RBD）和中和滴度，其中二分变量指示是否存在报告的反应，其显示了统计学显著性效应，对数转换滴度的估计变化范围为0.32 - 0.37（所有p < 0.01），表明在具有一种或多种不同严重程度的报告反应的受试者中具有更高的免疫原性。如本研究所报告的，NH居民中疫苗接种后反应的发生率显著降低，BNT 162 b2 mRNA疫苗似乎在该易感人群中耐受良好。如果在更大的人群中得到验证，反应原性的缺乏可能有助于指导临床医生优先考虑疫苗加强剂。反应原性在疗养院居民中显著轻微，总体而言，报告接种后反应的受试者产生了较高的抗体滴度。在线版本包含补充材料，可通过10.1007/s40520-021-01987-9获得。
The BNT162b2 SARS-CoV-2 mRNA vaccination has mitigated the burden of COVID-19 among residents of long-term care facilities considerably, despite being excluded from the vaccine trials. Data on reactogenicity (vaccine side effects) in this population are limited. To assess reactogenicity among nursing home (NH) residents. To provide a plausible proxy for predicting vaccine response among this population. We enrolled and sampled NH residents and community-dwelling healthcare workers who received the BNT162b2 mRNA vaccine, to assess local or systemic reactogenicity and antibody levels (immunogenicity). NH residents reported reactions at a much lower frequency and lesser severity than the community-dwelling healthcare workers. These reactions were mild and transient with all subjects experiencing more local than systemic reactions. Based on our reactogenicity and immunogenicity data, we developed a linear regression model predicting log-transformed anti-spike, anti-receptor-binding domain (RBD), and neutralizing titers, with a dichotomous variable indicating the presence or absence of reported reactions which revealed a statistically significant effect, with estimated shifts in log-transformed titers ranging from 0.32 to 0.37 (all p < 0.01) indicating greater immunogenicity in subjects with one or more reported reactions of varying severity. With a significantly lower incidence of post-vaccination reactions among NH residents as reported in this study, the BNT162b2 mRNA vaccine appears to be well-tolerated among this vulnerable population. If validated in larger populations, absence of reactogenicity could help guide clinicians in prioritizing vaccine boosters. Reactogenicity is significantly mild among nursing home residents and overall, subjects who reported post-vaccination reactions developed higher antibody titers. The online version contains supplementary material available at 10.1007/s40520-021-01987-9.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
82.9
作者：
Ebinger JE;Fert-Bober J;Printsev I;Wu M;Sun N;Prostko JC;Frias EC;Stewart JL;Van Eyk JE;Braun JG;Cheng S;Sobhani K
通讯作者：
Sobhani K
DOI：
10.3390/life11030249
发表时间：
2021-03-17
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Mathioudakis AG;Ghrew M;Ustianowski A;Ahmad S;Borrow R;Papavasileiou LP;Petrakis D;Bakerly ND
通讯作者：
Bakerly ND
影响因子：
2.6
作者：
Joelson, S;Joelson, IB;Wallander, MA
通讯作者：
Wallander, MA
影响因子：
11.8
作者：
Mueller, Lisa;Andree, Marcel;Schaal, Heiner
通讯作者：
Schaal, Heiner