Effect of aging on cellular mechanotransduction.

Effect of aging on cellular mechanotransduction.
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DOI:
10.1016/j.arr.2009.11.002
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发表时间:
2011-01
影响因子:
13.1
通讯作者:
Blough, Eric R.
Blough, Eric R.
中科院分区:
医学1区
文献类型:
--
作者:
Wu, Miaozong;Fannin, Jacqueline;Rice, Kevin M.;Wang, Bin;Blough, Eric R.

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老龄化正在成为一个关键的医疗保健问题,并成为社会日益增长的经济负担。机械转导是细胞感知、处理和响应机械刺激的能力,是一种重要的生理功能调节剂,已被发现在调节基因表达、蛋白质合成、细胞分化、组织生长以及最近的疾病病理生理学中发挥作用。在这里,我们将回顾这一领域的一些最新发现,并尝试在可能的情况下,呈现与几个选定的生理系统(包括肌肉骨骼、心血管、神经、呼吸系统和皮肤)衰老过程相关的机械转导的变化。
Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation, tissue growth, and most recently, the pathophysiology of disease. Here we will review some of the recent findings of this field and attempt, where possible, to present changes in mechanotransduction that are associated with the aging process in several selected physiological systems, including musculoskeletal, cardiovascular, neuronal, respiratory systems and skin.
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