Role of inflammatory signaling in atrial fibrillation.

Role of inflammatory signaling in atrial fibrillation.
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DOI:
10.1016/j.ijcard.2018.10.020
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发表时间:
2019-07-15
影响因子:
3.5
通讯作者:
Dobrev D
Dobrev D
中科院分区:
医学2区
文献类型:
--
作者:
Scott L Jr;Li N;Dobrev D

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心房颤动(AF)是最常见的心律失常,常伴有炎症反应增强。新出现的证据表明,炎症信号通路在心房电、钙处理和结构重塑的演变中起因果作用,这是房颤发展的基础。在这篇综述中,我们讨论了支持炎症指标和AF发展之间的关联的临床证据,AF的分子和细胞机制,这似乎涉及多个典型的炎症通路,以及抗炎治疗方法在AF预防/治疗中的潜力。
Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced inflammatory response. Emerging evidence point to a causal role of inflammatory signaling pathways in the evolution of atrial electrical, calcium handling and structural remodeling, which create the substrate of AF development. In this review, we discuss the clinical evidence supporting the association between inflammatory indices and AF development, the molecular and cellular mechanisms of AF, which appear to involve multiple canonical inflammatory pathways, and the potential of anti-inflammatory therapeutic approaches in AF prevention/treatment.
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