Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage.
Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage.
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DOI：
10.3389/fneur.2018.00926
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发表时间：
2018
影响因子：
3.4
通讯作者：
Klijn CJM
中科院分区：
文献类型：
--
作者：
Freeze WM;Jacobs HIL;Schreuder FHBM;van Oostenbrugge RJ;Backes WH;Verhey FR;Klijn CJM
背景和目的：高血压血管病和淀粉样脑血管病是两种最常见的脑部小血管疾病。这两种形式都与原发性脑出血的发生有关，但自发性血管破裂的病理生理机制尚不清楚。本研究对血脑屏障功能障碍在脑小血管疾病所致自发性脑出血病因中的作用进行了系统的综述。方法：我们在Medline(1946-2018)和Embase(1974-2018)中搜索与脑出血或脑微出血相关的血脑屏障功能障碍的动物和人类研究。结果：在26项符合条件的研究中，10项是动物研究，16项是人类研究。作者在所有四项涉及高血压血管病相关脑出血的动物研究(n=32只高血压动物，包括在所有四项研究中)和六项关于脑淀粉样血管病相关脑出血的研究中的四项(n=47)中发现了血脑屏障功能障碍的迹象。在对人类的研究中，6项针对脑淀粉样血管病相关脑出血患者的研究中有5项(n=117)，9项研究中有7项研究混合或未指明潜在病因的脑出血(n=489)发现了血脑屏障功能障碍的迹象。一项高血压血管病变相关脑出血的尸检研究(n=82)没有发现血脑屏障异常的证据。结论：在26项研究中有20项发现了血脑屏障功能障碍的迹象。血脑屏障的完整性值得进一步研究，以确定自发性脑出血的潜在治疗靶点。
Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease. Both forms are associated with the development of primary intracerebral hemorrhage, but the pathophysiological mechanisms underlying spontaneous vessel rupture remain unknown. This work constitutes a systematic review on blood-brain barrier dysfunction in the etiology of spontaneous intracerebral hemorrhage due to cerebral small vessel disease. Methods: We searched Medline (1946–2018) and Embase (1974–2018) for animal and human studies reporting on blood-brain barrier dysfunction associated with intracerebral hemorrhage or cerebral microbleeds. Results: Of 26 eligible studies, 10 were animal studies and 16 were in humans. The authors found indications for blood-brain barrier dysfunction in all four animal studies addressing hypertensive vasculopathy-related intracerebral hemorrhage (n = 32 hypertensive animals included in all four studies combined), and in four of six studies on cerebral amyloid angiopathy-related intracerebral hemorrhage (n = 47). Of the studies in humans, five of six studies in patients with cerebral amyloid angiopathy-related intracerebral hemorrhage (n = 117) and seven out of nine studies examining intracerebral hemorrhage with mixed or unspecified underlying etiology (n = 489) found indications for blood-brain barrier dysfunction. One post-mortem study in hypertensive vasculopathy-related intracerebral hemorrhage (n = 82) found no evidence for blood-brain barrier abnormalities. Conclusions: Signs of blood-brain barrier dysfunction were found in 20 out of 26 studies. Blood-brain barrier integrity deserves further investigation with a view to identification of potential treatment targets for spontaneous intracerebral hemorrhage.
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影响因子：
12.7
作者：
Grinberg LT;Thal DR
通讯作者：
Thal DR
影响因子：
4.5
作者：
Herzog R;Álvarez-Pasquin MJ;Díaz C;Del Barrio JL;Estrada JM;Gil Á
通讯作者：
Gil Á
影响因子：
8.3
作者：
Hartz AM;Bauer B;Soldner EL;Wolf A;Boy S;Backhaus R;Mihaljevic I;Bogdahn U;Klünemann HH;Schuierer G;Schlachetzki F
通讯作者：
Schlachetzki F
影响因子：
9.9
作者：
Jolink, Wilmar M. T.;Klijn, Catharina J. M.;Vaartjes, Ilonca
通讯作者：
Vaartjes, Ilonca
影响因子：
8.3
作者：
Greenberg, SM;Eng, JA;Rosand, J
通讯作者：
Rosand, J