TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog.
TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog.
复制标题
DOI：
10.1016/j.dci.2010.11.013
复制
发表时间：
2011-04
影响因子：
2.9
通讯作者：
Godzik, Adam
中科院分区：
文献类型：
--
作者：
Zhang, Qing;Zmasek, Christian M.;Cai, Xiaohui;Godzik, Adam
关键词：
Toll/白细胞介素-1受体（TIR）结构域蛋白通过一系列特异性蛋白质相互作用连接免疫信号通路，在动植物防御病原体中发挥重要作用。其中SARM是唯一一个可以负调节TLR信号传导的含有TIR结构域的适配器。通过广泛的系统发育分析，我们发现SARM与具有TIR结构域的细菌蛋白密切相关，这表明该家族与其他动物含TIR的衔接子具有不同的进化历史，可能通过从细菌到动物的横向基因转移而出现。我们还显示了几个类似的，独立的转移事件的证据，没有一个，但是，在脊椎动物中存活。动物SARM适配器和具有TIR结构域的细菌蛋白之间的进化关系说明了细菌含TIR的蛋白在调节真核生物免疫应答中发挥的可能作用，以及这种机制如何可能被真核生物本身所适应。
Toll/interleukin-1 receptor (TIR) domain-containing proteins play important roles in defense against pathogens in both animals and plants, connecting the immunity signaling pathways via a chain of specific protein–protein interactions. Among them is SARM, the only TIR domain-containing adaptor that can negatively regulate TLR signaling. By extensive phylogenetic analysis, we show here that SARM is closely related to bacterial proteins with TIR domains, suggesting that this family has a different evolutionary history from other animal TIR-containing adaptors, possibly emerging via a lateral gene transfer from bacteria to animals. We also show evidence of several similar, independent transfer events, none of which, however, survived in vertebrates. An evolutionary relationship between the animal SARM adaptor and bacterial proteins with TIR domains illustrates the possible role that bacterial TIR-containing proteins play in regulating eukaryotic immune responses and how this mechanism was possibly adapted by the eukaryotes themselves.
登录
查看更多内容
影响因子：
4.8
作者：
Khan, JA;Brint, EK;Tong, L
通讯作者：
Tong, L
影响因子：
1.7
作者：
Desper, R;Gascuel, O
通讯作者：
Gascuel, O
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
影响因子：
3.1
作者：
Newman, RM;Salunkhe, P;Reed, JC
通讯作者：
Reed, JC
影响因子：
4.8
作者：
Chan, Siew Leong;Low, Lieh Yoon;Pascual, Jaime
通讯作者：
Pascual, Jaime