APOE4 Genotype Exerts Greater Benefit in Lowering Plasma Cholesterol and Apolipoprotein B than Wild Type (E3/E3), after Replacement of Dietary Saturated Fats with Low Glycaemic Index Carbohydrates.
APOE4 Genotype Exerts Greater Benefit in Lowering Plasma Cholesterol and Apolipoprotein B than Wild Type (E3/E3), after Replacement of Dietary Saturated Fats with Low Glycaemic Index Carbohydrates.
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DOI：
10.3390/nu10101524
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发表时间：
2018-10-17
期刊：
影响因子：
5.9
通讯作者：
Lovegrove JA
中科院分区：
文献类型：
--
作者：
Griffin BA;Walker CG;Jebb SA;Moore C;Frost GS;Goff L;Sanders TAB;Lewis F;Griffin M;Gitau R;Lovegrove JA
我们在一项五臂、随机对照、平行饮食干预试验（“RISCK”研究）的二次分析数据中检查了APOE基因型对血脂和血糖的影响，以研究用单不饱和脂肪（MUFA）或高或低血糖指数（GI）的碳水化合物替代饱和脂肪酸（SFA）对CVD危险因素和胰岛素敏感性的影响。我们检测了APOE基因型（携带E2和E4等位基因与E3/E3）对基线时血浆脂质、脂蛋白和葡萄糖稳态的影响（n = 469），以及对24周饮食干预后这些变量变化的影响（n = 389）。基线时，E2（n = 70）、E4（n = 125）和E3/E3（n = 274）携带者的血浆总胆固醇水平存在显著差异（TC，p = 0.001），低密度脂蛋白胆固醇（LDL-C，p < 0.0001）、载脂蛋白B（apo B，p < 0.0001）和总高密度脂蛋白胆固醇比（TC：HDL-C，p = 0.002），血浆浓度以E4 > E3/E3 > E2的顺序降低。干预后，有证据表明，饮食x基因型的相互作用，使TC显著降低（p = 0.02）和载脂蛋白B（p = 0.006）在E4携带者中，当SFA在低脂饮食中被低GI碳水化合物替代时，（TC −0.28 mmol/L p = 0.03; apo B −0.1 g/L p = 0.02），当SFA被MUFA和高GI碳水化合物替代时，TC相对增加（与E3/E3相比）（TC 0.3 mmol/L，p = 0.03）。在E2携带者中（与E3/E3相比），当SFA被MUFA和低GI碳水化合物0.46 mmol/L（p = 0.001）取代时，三酰甘油（TAG）增加。APOE基因型和饮食对葡萄糖稳态指标的变化没有显著的相互作用。总之，APOE基因型的变化导致对用MUFA和低GI碳水化合物替代SFA的脂质反应的差异效应。
We examined the impact of APOE genotype on plasma lipids and glucose in a secondary analysis of data from a five-arm, randomised controlled, parallel dietary intervention trial (‘RISCK’ study), to investigate the impact of replacing saturated fatty acids (SFA) with either monounsaturated fat (MUFA) or carbohydrate of high or low glycaemic index (GI) on CVD risk factors and insulin sensitivity. We tested the impact of APOE genotype (carriage of E2 and E4 alleles versus E3/E3), determined retrospectively, on plasma lipids, lipoproteins and glucose homeostasis at baseline (n = 469), and on the change in these variables after 24 weeks of dietary intervention (n = 389). At baseline, carriers of E2 (n = 70), E4 (n = 125) and E3/E3 (n = 274) expressed marked differences in total plasma cholesterol (TC, p = 0.001), low density lipoprotein cholesterol (LDL-C, p < 0.0001), apolipoprotein B (apo B, p < 0.0001) and total to high density lipoprotein cholesterol ratio (TC:HDL-C, p = 0.002), with plasma concentrations decreasing in the order E4 > E3/E3 > E2. Following intervention, there was evidence of a significant diet x genotype interaction with significantly greater decreases in TC (p = 0.02) and apo B (p = 0.006) among carriers of E4 when SFA was replaced with low GI carbohydrate on a lower fat diet (TC −0.28 mmol/L p = 0.03; apo B −0.1 g/L p = 0.02), and a relative increase in TC (in comparison to E3/E3) when SFA was replaced with MUFA and high GI carbohydrates (TC 0.3 mmol/L, p = 0.03). Among carriers of E2 (compared with E3/E3) there was an increase in triacylglycerol (TAG) when SFA was replaced with MUFA and low GI carbohydrates 0.46 mmol/L p = 0.001). There were no significant interactions between APOE genotype and diet for changes in indices of glucose homeostasis. In conclusion, variations in APOE genotype led to differential effects on the lipid response to the replacement of SFA with MUFA and low GI carbohydrates.
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影响因子：
105.7
作者：
COX, C;MANN, J;BALL, M
通讯作者：
BALL, M
影响因子：
--
作者：
DENKE, MA;GRUNDY, SM
通讯作者：
GRUNDY, SM
影响因子：
7.1
作者：
Jakobsen, Marianne U.;Dethlefsen, Claus;Overvad, Kim
通讯作者：
Overvad, Kim
影响因子：
5.3
作者：
Carvalho-Wells, Andrew L.;Jackson, Kim G.;Minihane, Anne M.
通讯作者：
Minihane, Anne M.
影响因子：
15.9
作者：
GREGG, RE;ZECH, LA;BREWER, HB
通讯作者：
BREWER, HB