Pathophysiological Basis for the Formation of the Tumor Microenvironment.
Pathophysiological Basis for the Formation of the Tumor Microenvironment.
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DOI：
10.3389/fonc.2016.00066
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发表时间：
2016
影响因子：
4.7
通讯作者：
Vaupel P
中科院分区：
文献类型：
--
作者：
Horsman MR;Vaupel P
微环境条件差是实体瘤的一个特征。发生这种情况的原因是肿瘤血管供应，由正常宿主血管生成过程发展而来，通常不能满足肿瘤肿块生长对氧气和营养的需求。低氧合（缺氧）区域被认为是最关键的缺陷，因为有充分的证据表明，它在影响对常规放疗和化疗治疗的反应方面发挥着重要作用，并影响恶性进展，包括原发性肿瘤的侵袭性生长和复发及其转移性扩散。因此，重要的重点放在寻找临床适用的方法来识别那些含有缺氧的肿瘤和现实的方法来靶向这种缺氧。然而，大多数研究认为缺氧是一个单一的实体，但我们现在知道它是多因素的。此外，缺氧通常与其他微环境参数相关，如间质液压力升高、糖酵解、低pH和生物能量状态降低，这些也会影响缺氧的作用。在这里，我们回顾了缺氧的各个方面，但也讨论了与缺氧相关的其他微环境参数的作用。
Poor microenvironmental conditions are a characteristic feature of solid tumors. Such conditions occur because the tumor vascular supply, which develops from the normal host vasculature by the process of angiogenesis, is generally inadequate in meeting the oxygen and nutrient demands of the growing tumor mass. Regions of low oxygenation (hypoxia) is believed to be the most critical deficiency, since it has been well documented to play a significant role in influencing the response to conventional radiation and chemotherapy treatments, as well as influencing malignant progression in terms of aggressive growth and recurrence of the primary tumor and its metastatic spread. As a result, significant emphasis has been placed on finding clinically applicable approaches to identify those tumors that contain hypoxia and realistic methods to target this hypoxia. However, most studies consider hypoxia as a single entity, yet we now know that it is multifactorial. Furthermore, hypoxia is often associated with other microenvironmental parameters, such as elevated interstitial fluid pressure, glycolysis, low pH, and reduced bioenergetic status, and these can also influence the effects of hypoxia. Here, we review the various aspects of hypoxia, but also discuss the role of the other microenvironmental parameters associated with hypoxia.
影响因子：
8.8
作者：
Vaupel, P;Kelleher, D K;Engel, T
通讯作者：
Engel, T