Depression and nonadherence predict mortality in hemodialysis treated end-stage renal disease patients.
Depression and nonadherence predict mortality in hemodialysis treated end-stage renal disease patients.
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DOI：
10.1111/j.1542-4758.2012.00688.x
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Cukor D
中科院分区：
文献类型：
--
作者：
Rosenthal Asher D;Ver Halen N;Cukor D
对抑郁症对 HD 患者死亡率影响的科学评估得出的结果好坏参半，最近、更严格的研究发现了两者之间的显着关系。在这项研究中，对来自北美城市医院的 130 名 HD 患者进行了抑郁情绪评估，并进行了长达 5 年的观察。在修正的 Cox 回归模型中，年龄、性别、透析年份、疾病严重程度和糖尿病状况保持恒定，抑郁情绪成为死亡率的适度但显着的预测因子（相对风险 = 1.05，95% CI 1.01 – 1.08）。当根据抑郁情绪的严重程度对受试者进行分组时，具有严重抑郁情绪的受试者的死亡时间显着缩短（β = .452，p = .044）。在 85 名受试者组成的亚组中，自我报告的药物依从性也可预测死亡率，较高的不依从性与死亡风险增加相关。本文为有关抑郁症和 HD 人群生存率降低的新兴文献提供了支持，并开始研究了解其潜在机制。
The scientific evaluation of depression's impact on mortality in HD patients has yielded mixed results, with the more recent, more rigorous studies detecting a significant relationship. In this study 130 HD patients from an urban North American hospital were evaluated for depressive affect and then observed for up to 5 years. In a corrected Cox regression model, that held constant age, gender, dialysis vintage, illness severity and diabetic status, depressive affect emerged as a modest but significant predictor of mortality (relative risk = 1.05, 95% CI 1.01 – 1.08). When the subjects were divided according to depressive affect severity, those with severe depressive affect had significantly shorter time to death (beta = .452, p = .044). In a sub-group of 85 subjects, self-reported medication adherence was also predictive of mortality, with higher rates of non-adherence being associated with increased mortality risk. This paper lends support to the burgeoning literature on depression and reduced survival in HD populations, as well as begins the investigation of understanding the underlying mechanisms.
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影响因子：
19.6
作者：
Cukor, Daniel;Rosenthal, Deborah S.;Kimmel, Paul L.
通讯作者：
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DOI：
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发表时间：
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作者：
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