A new method to measure cortical growth in the developing brain.
A new method to measure cortical growth in the developing brain.
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一种测量发育中大脑皮质生长的新方法。
DOI：
10.1115/1.4002430
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Bayly,PhilipV
中科院分区：
文献类型：
--
作者：
Knutsen,AndrewK;Chang,YulinV;Grimm,CindyM;Phan,Ly;Taber,LarryA;Bayly,PhilipV
大脑皮层的折叠是高等哺乳动物大脑发育的一个关键阶段，但折叠的生物力学仍然不完全清楚。在折叠过程中，皮质表面的生长是不均匀和各向异性的。我们开发并应用了一种新的技术来测量从单个动物或人类受试者的纵向磁共振成像（MRI）研究中表面生长的空间和方向变化。MRI提供大脑在不同发育阶段的高分辨率3D图像体积。通过分割这些体积获得大脑皮层的表面表示。两个时间之间的局部表面生长的估计需要在那些时间测量的表面之间建立点对点对应（“配准”）。在这里，我们提出了一种新的方法，其中的能量函数是最小化的球面上求解偏微分方程的两个表面的注册。能量函数包括由于变形引起的应变能量项和由于表面特征之间的失配引起的“误差能量”项。该算法采用有限元方法实现，使表面特征近似对齐，同时最大限度地减少没有明确匹配标准的区域的变形。该方法进行了验证，通过应用到三个模拟的测试情况下，并施加到雪貂皮层在折叠过程中的生长特征。皮质表面由出生后14天、21天和28天在体内采集的MRI数据创建。变形梯度和拉格朗日应变张量描述了在这个区间的增长的运动学。这些定量的结果照亮皮质折叠过程中的空间，时间和方向的增长模式。
Folding of the cerebral cortex is a critical phase of brain development in higher mammals but the biomechanics of folding remain incompletely understood. During folding, the growth of the cortical surface is heterogeneous and anisotropic. We developed and applied a new technique to measure spatial and directional variations in surface growth from longitudinal magnetic resonance imaging (MRI) studies of a single animal or human subject. MRI provides high resolution 3D image volumes of the brain at different stages of development. Surface representations of the cerebral cortex are obtained by segmentation of these volumes. Estimation of local surface growth between two times requires establishment of a point-to-point correspondence (“registration”) between surfaces measured at those times. Here we present a novel approach for the registration of two surfaces in which an energy function is minimized by solving a partial differential equation on a spherical surface. The energy function includes a strain-energy term due to distortion and an “error energy” term due to mismatch between surface features. This algorithm, implemented with the finite element method, brings surface features into approximate alignment while minimizing deformation in regions without explicit matching criteria. The method was validated by application to three simulated test cases and applied to characterize growth of the ferret cortex during folding. Cortical surfaces were created from MRI data acquired in vivo at 14 days, 21 days, and 28 days of life. Deformation gradient and Lagrangian strain tensors describe the kinematics of growth over this interval. These quantitative results illuminate the spatial, temporal, and directional patterns of growth during cortical folding.
影响因子：
3.7
作者：
Kroenke, Christopher D.;Taber, Erin N.;Bayly, Philip V.
通讯作者：
Bayly, Philip V.
时间序列微分同胚度量映射和并行传输跟踪时间相关的形状变化
影响因子：
5.7
作者：
A. Qiu;M. Albert;L. Younes;M. Miller
通讯作者：
M. Miller
影响因子：
10.9
作者：
Shi, Yonggang;Thompson, Paul M.;Toga, Arthur W.
通讯作者：
Toga, Arthur W.