Glucosamine Modified the Surface of pH-Responsive Poly(2-(diethylamino)ethyl Methacrylate) Brushes Grafted on Hollow Mesoporous Silica Nanoparticles as Smart Nanocarrier.
Glucosamine Modified the Surface of pH-Responsive Poly(2-(diethylamino)ethyl Methacrylate) Brushes Grafted on Hollow Mesoporous Silica Nanoparticles as Smart Nanocarrier.
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DOI：
10.3390/polym12112749
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发表时间：
2020-11-20
期刊：
影响因子：
5
通讯作者：
Alswieleh A
中科院分区：
文献类型：
--
作者：
Beagan A;Lahmadi S;Alghamdi A;Halwani M;Almeataq M;Alhazaa A;Alotaibi K;Alswieleh A
本文采用表面引发的ARGET ATRP技术合成了pH响应性的聚甲基丙烯酸二乙氨基乙酯（PDEAEMA）刷锚定在中空介孔二氧化硅纳米粒子（HMSN-PDEAEMA）上。HMSNs的平均大小约为1.5 × 10 ~（-1）。340 nm，具有90 nm中孔二氧化硅壳。接枝PDEAEMA刷的干厚度估计为约30 nm，如通过SEM和TEM估计的。通过XPS证实，PDEAMA刷表面上的卤素基团成功地与葡萄糖胺衍生。通过DLS研究了pH对杂化纳米颗粒尺寸的影响。所制备的纳米颗粒的尺寸从约100 nm减小到约100 nm。950 nm，在酸性介质中，由于PDEAEMA中叔胺的去质子化作用，在碱性介质中500 nm。PDEAEMA修饰的HMSNs纳米载体有效地负载了阿霉素（DOX），负载容量约为100 μ g/ml。百分之六十四DOX以相对受控的pH触发方式从混合纳米颗粒释放。细胞毒性研究表明，与游离DOX相比，DOX@HMSN-PDEAEMA-氨基葡萄糖在低药物浓度下显示出杀死乳腺癌细胞（MCF-7和MCF-7/ADR）的强能力。
This work presents the synthesis of pH-responsive poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA) brushes anchored on hollow mesoporous silica nanoparticles (HMSN-PDEAEMA) via a surface-initiated ARGET ATRP technique. The average size of HMSNs was ca. 340 nm, with a 90 nm mesoporous silica shell. The dry thickness of grafted PDEAEMA brushes was estimated to be ca 30 nm, as estimated by SEM and TEM. The halogen group on the surface of PDEAMA brushes was successfully derivatized with glucosamine, as confirmed by XPS. The effect of pH on the size of the hybrid nanoparticles was investigated by DLS. The size of fabricated nanoparticle decreased from ca. 950 nm in acidic media to ca. 500 nm in basic media due to the deprotonation of tertiary amine in the PDEAEMA. The PDEAEMA modified HMSNs nanocarrier was efficiently loaded with doxorubicin (DOX) with a loading capacity of ca. 64%. DOX was released in a relatively controlled pH-triggered manner from hybrid nanoparticles. The cytotoxicity studies demonstrated that DOX@HMSN-PDEAEMA-Glucosamine showed a strong ability to kill breast cancer cells (MCF-7 and MCF-7/ADR) at low drug concentrations, in comparison to free DOX.
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