Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea.
Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea.
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DOI：
10.3390/ijerph19042404
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发表时间：
2022-02-19
影响因子：
--
通讯作者：
Bell ML
中科院分区：
文献类型：
--
作者：
Heo S;Kim H;Kim S;Choe SA;Byun G;Lee JT;Bell ML
Bone health is a major concern for aging populations globally. Osteoporosis and bone mineral density are associated with air pollution, but less is known about the impacts of air pollution on osteoporotic fracture. We aimed to assess the associations between long-term air pollution exposure and risk of osteoporotic fracture in seven large Korean cities. We used Cox proportional hazard models to estimate hazard rations (HRs) of time-varying moving window of past exposures of particulate matter (PM10), sulfur dioxide (SO2), carbon monoxide (CO), nitrogen dioxide (NO2), and ozone (O3) for osteoporotic fracture in Korean adults (age ≥ 50 years) in the National Health Insurance Service-National Sample Cohort data, followed 2002 to 2015. HRs were calculated for an interquartile range (IQR) increase. Comorbidity and prescription associated with osteoporosis, age, sex, body mass index, health behaviors, and income were adjusted in the models. Effect modification by age, sex, exercise, and income was examined. We assessed 56,467 participants over 535,481 person-years of follow up. Linear and positive exposure-response associations were found for SO2, while PM10 and NO2 showed nonlinear associations. SO2 was associated with osteoporosis-related fracture with marginal significance (HR for an IQR [2 ppb] increase = 1.04, 95% CI: 1.00, 1.09). The SO2 HR estimates were robust in analyses applying various moving windows of exposure (from one to three years of past exposure) and two-pollutant models. The central HR estimate of O3 implied positive associations but was not significant (HR for 0.007 ppm increase = 1.01, 95% CI: 0.97, 1.06). PM10, CO, and NO2 did not show associations. Vulnerable groups by sex, age, exercise, and income varied across air pollutants and there was no evidence of effect modifications. Long-term exposure to SO2, but not PM10, CO, NO2 and O3, was associated with increased osteoporotic fracture risks in Korean adults.
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DOI：
10.3390/ijerph17249165
发表时间：
2020-12-08
影响因子：
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作者：
Lin YH;Wang CF;Chiu H;Lai BC;Tu HP;Wu PY;Huang JC;Chen SC
通讯作者：
Chen SC
香港老年中国老年人的绿色空间与骨矿物质密度变化和入射骨折的关联：OS先生和OS女士研究。
影响因子：
8.3
作者：
Lin J;Leung J;Yu B;Woo J;Kwok T;Ka-Lun Lau K
通讯作者：
Ka-Lun Lau K
影响因子：
2.1
作者：
Meng, ZQ
通讯作者：
Meng, ZQ
影响因子：
11.8
作者：
Kim, Honghyok;Kim, Hyomi;Lee, Jong-Tae
通讯作者：
Lee, Jong-Tae
影响因子：
--
作者：
Jung, Hyoung-Seok;Nho, Jae-Hwi;Lee, Young-Kyun
通讯作者：
Lee, Young-Kyun