Expression and correlation of Lewis y antigen and TGF-β1 in ovarian epithelial carcinoma.
Expression and correlation of Lewis y antigen and TGF-β1 in ovarian epithelial carcinoma.
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DOI：
10.3892/or.2011.1575
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发表时间：
2012-04
期刊：
影响因子：
4.2
通讯作者：
Iwamori M
中科院分区：
文献类型：
--
作者：
Wang ST;Liu JJ;Wang CZ;Lin B;Hao YY;Wang YF;Gao S;Qi Y;Zhang SL;Iwamori M
刘易斯y是细胞表面糖缀合物携带的二岩藻糖基化低聚糖。刘易斯y升高常见于上皮来源的癌症。本研究旨在检测刘易斯y抗原和转化生长因子β1（TGF-β1）在卵巢上皮性肿瘤中的表达及临床意义，并探讨二者之间的相关性。应用免疫组织化学方法检测60例卵巢上皮性恶性肿瘤、20例交界性卵巢肿瘤、20例良性卵巢肿瘤和10例正常卵巢组织中刘易斯y抗原和TGF-β1的表达。免疫荧光双标记法检测刘易斯y抗原与TGF-β1的相关性。卵巢上皮性癌组织中刘易斯y抗原阳性率为88.33%，显著高于交界性卵巢肿瘤（60.00%）（P<0.05）、良性卵巢肿瘤（35.00%）（P<0.01）和正常卵巢组织（0%）（P<0.01）。TGF-β1在卵巢上皮性癌中的阳性表达率为78.33%，显著高于卵巢良性肿瘤（65.00%）（P<0.05）与正常卵巢组织比较TGF-β1和刘易斯y的阳性表达率与淋巴结转移、组织学类型、分化程度和临床分期无关（P>0.05）。刘易斯y抗原和TGF-β1的表达与上皮性癌的发生呈正相关。刘易斯y、TGF-β1与卵巢癌的发生密切相关。刘易斯y抗原表达的改变可引起TGF-β1表达的改变。刘易斯y可通过促进TGF-β1的异常表达、促进血管生成及其信号转导通路的改变，增强卵巢癌细胞的生长和侵袭能力。本研究为卵巢癌生物治疗的发展提供了理论依据。
Lewis y is a difucosylated oligosaccharide carried by glycoconjugates on the cell surface. Elevation of Lewis y is frequently observed in epithelial-derived cancers. This study aimed to detect the expression and clinical significance of the Lewis y antigen and TGF-β1 (transforming growth factor β1) in ovarian epithelial tumors, and to evaluate the correlation between them. Immunohistochemical staining was used to detect the expression of Lewis y antigen and TGF-β1 in 60 cases of ovarian epithelial malignant tumors, 20 cases of borderline ovary tumors, 20 cases of benign ovary tumors and 10 cases of normal ovarian tissues. An immunofluorescence double labeling method was also used to detect the correlation between Lewis y antigen and TGF-β1. The positive rates of Lewis y antigen in ovarian epithelial cancer tissues was 88.33%, significantly higher compared to those of borderline ovarian tumors (60.00%) (P<0.05), benign ovarian tumors (35.00%) (P<0.01) and normal ovarian tissues (0%) (P<0.01). Its expression was not associated with clinical parameters; the positive rates of TGF-β1 in ovarian epithelial cancers were 78.33%, significantly higher compared to those of benign ovarian tumors (65.00%) (P<0.05) and normal ovarian tissues (40.00%) (P<0.05); the positive rates of the TGF-β1 and Lewis y were not associated with metastasis of lymph nodes and histological types, differentiation degree and clinical stage (P>0.05). Expression of Lewis y antigen and TGF-β1 was significantly positively associated with epithelial carcinoma. Close correlation between Lewis y, TGF-β1 and ovarian cancer was observed. Altered expression of Lewis y antigen may cause changes in TGF-β1 expression. Lewis y can increase the growth of ovarian cancer cells and the invasion ability by promoting TGF-β1 abnormal expression and by promoting angiogenesis and a change in its signal transduction pathway. This study provides theoretical evidence for the development of ovarian cancer biological treatments.
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