The risk of developing second primary malignancies among colorectal cancer patients.
The risk of developing second primary malignancies among colorectal cancer patients.
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结直肠癌患者发生第二原发恶性肿瘤的风险。
DOI：
10.18632/aging.204250
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发表时间：
2022-08-26
期刊：
影响因子：
5.2
通讯作者：
Cui, Binbin
中科院分区：
文献类型：
--
作者：
Du, Songtao;Li, Yayun;Sun, Huiyan;Deng, Guangtong;Tang, Siyuan;Zeng, Furong;Zhang, Bomiao;Cui, Binbin
背景资料：越来越多的年轻结直肠癌（CRC）幸存者导致了对继发性原发性恶性肿瘤（SPM）风险的持续关注。在此，我们旨在全面探讨不同滞后期限制的CRC幸存者中总SPM和部位特异性SPM的合并标准化发生率（SIR）。研究方法：检索Pubmed、Embase、科克伦图书馆和Web of science数据库，以确定报告CRC后SPM的SIR的任何研究，直至2021年8月。使用固定/随机效应模型汇总了对滞后期有不同限制的总体和研究中心特异性SIR。结果：共纳入42篇全文文献，其中包括1524236例CRC幸存者和166210例SPM患者。汇总数据显示，在对延迟期有不同限制的CRC幸存者中，所有SPM的SIR均增加（无滞后期限制，SIR = 1.15，95% CI = [1.08-1.23]; 1年滞后，1.16 [1.10-1.23]; 5年滞后，1.18 [1.09-1.28]; 10年滞后，1.24 [1.11-1.39]）。结论是一致的结直肠肿瘤，子宫体和小肠肿瘤的不同限制滞后期。然而，有限的证据表明CRC幸存者与前列腺、乳腺（女性）、卵巢、胃、膀胱、肾脏、甲状腺、骨和软组织SPM之间存在关联。结论：结直肠癌幸存者与SPM风险增加相关，尤其是结直肠、子宫体和小肠肿瘤。进一步的研究应探讨这些肿瘤的CRC幸存者的风险，从而为未来的后续护理提供参考。
Background: The increasing number of young colorectal cancer (CRC) survivors has led to ongoing concerns about the risk of secondary primary malignancies (SPMs). Here, we intended to comprehensively explore the pooled standardized incidence rates (SIRs) for total and site-specific SPMs in CRC survivors with different restriction to lag period. Methods: Pubmed, Embase, Cochrane Library, and Web of science databases were searched to identify any studies reporting the SIRs of SPM following CRC until August 2021. Total and site-specific SIRs with different restriction to lag period were pooled using fixed/random effect models. Results: A total of 42 full-text publications with more than 1, 524, 236 CRC survivors and 166, 210 SPM patients were included in the meta-analysis. Pooled data showed an increased SIRs for all SPMs in CRC survivors with different restriction to lag period (no restriction to lag period, SIR = 1.15, 95% CI = [1.08–1.23]; 1-year lag, 1.16 [1.10–1.23]; 5-year lag, 1.18 [1.09–1.28]; 10-year lag, 1.24 [1.11–1.39]). The conclusions were consistent for neoplasms of colorectum, corpus uteri, and small intestine with different restriction to lag period. However, limited evidence was presented for associations between CRC survivors and SPM for prostate, breast (female), ovarian, stomach, urinary bladder, kidney, thyroid, bone and soft tissue. Conclusion: CRC survivors are associated with an increased risk of SPMs, especially neoplasms of colorectum, corpus uteri, and small intestine. Further studies should explore the risks for these neoplasms in CRC survivors, thus providing the reference for future follow-up care.
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影响因子：
3.8
作者：
Coyte A;Morrison DS;McLoone P
通讯作者：
McLoone P
影响因子：
3.7
作者：
Guan, Xu;Jin, Yinghu;Wang, Xishan
通讯作者：
Wang, Xishan
影响因子：
51.1
作者：
Bright, Chloej;Reulen, Raoul C.;Hawkins, Michael M.
通讯作者：
Hawkins, Michael M.
影响因子：
51.1
作者：
de Gonzalez, Amy Berrington;Curtis, Rochelle E.;Kry, Stephen F.;Gilbert, Ethel;Lamart, Stephanie;Berg, Christine D.;Stovall, Marilyn;Ron, Elaine
通讯作者：
Ron, Elaine
影响因子：
39.2
作者：
Green, RJ;Metlay, JP;Haller, DG
通讯作者：
Haller, DG