Second primary cancer risk - the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study.
Second primary cancer risk - the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study.
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DOI：
10.1186/1471-2407-14-272
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发表时间：
2014-04-18
期刊：
影响因子：
3.8
通讯作者：
McLoone P
中科院分区：
文献类型：
--
作者：
Coyte A;Morrison DS;McLoone P
有证据表明癌症幸存者患第二原发癌症的风险增加。风险因素和诊断技术流行率的变化可能影响了最近的风险。我们调查了英国苏格兰西部 2000 年至 2004 年间诊断出患有癌症的成年人中第二原发癌症的发病率 (n = 57,393)。我们使用美国国家癌症研究所监测流行病学和最终结果以及国际癌症研究机构对多种原发性癌症的定义，并以 95% 置信区间 (CI) 估计间接标准化发病率 (SIR)。诊断后的前 60 天内癌症发病率很高（SIR = 2.36，95% CI = 2.12 至 2.63）。当排除这一时期时，风险并未增加，但对于某些患者群体来说风险很高；特别是年龄 <50 岁的乳腺癌女性 (SIR = 2.13, 95% CI = 1.58 至 2.78)、膀胱癌 (SIR = 1.41, 95% CI = 1.19 至 1.67) 和头颈癌 (SIR = 1.93, 95%) 患者CI = 1.67 至 2.21) 癌症。头颈癌患者患肺癌（SIR = 3.75，95% CI = 3.01至4.62）、食管癌（SIR = 4.62，95% CI = 2.73至7.29）和其他头颈肿瘤（SIR = 6.10， 95% CI = 4.17 至 8.61）。膀胱癌患者患肺癌（SIR = 2.18，95% CI = 1.62至2.88）和前列腺癌（SIR = 2.41，95% CI = 1.72至3.30）的风险增加。第二原发癌症的相对风险可能比之前报道的要小。患有乳腺癌的绝经前妇女以及患有恶性黑色素瘤、膀胱癌和头颈癌的患者可能会受益于加强监测和建议，以避免已知的危险因素。
There is evidence that cancer survivors are at increased risk of second primary cancers. Changes in the prevalence of risk factors and diagnostic techniques may have affected more recent risks. We examined the incidence of second primary cancer among adults in the West of Scotland, UK, diagnosed with cancer between 2000 and 2004 (n = 57,393). We used National Cancer Institute Surveillance Epidemiology and End Results and International Agency for Research on Cancer definitions of multiple primary cancers and estimated indirectly standardised incidence ratios (SIR) with 95% confidence intervals (CI). There was a high incidence of cancer during the first 60 days following diagnosis (SIR = 2.36, 95% CI = 2.12 to 2.63). When this period was excluded the risk was not raised, but it was high for some patient groups; in particular women aged <50 years with breast cancer (SIR = 2.13, 95% CI = 1.58 to 2.78), patients with bladder (SIR = 1.41, 95% CI = 1.19 to 1.67) and head & neck (SIR = 1.93, 95% CI = 1.67 to 2.21) cancer. Head & neck cancer patients had increased risks of lung cancer (SIR = 3.75, 95% CI = 3.01 to 4.62), oesophageal (SIR = 4.62, 95% CI = 2.73 to 7.29) and other head & neck tumours (SIR = 6.10, 95% CI = 4.17 to 8.61). Patients with bladder cancer had raised risks of lung (SIR = 2.18, 95% CI = 1.62 to 2.88) and prostate (SIR = 2.41, 95% CI = 1.72 to 3.30) cancer. Relative risks of second primary cancers may be smaller than previously reported. Premenopausal women with breast cancer and patients with malignant melanomas, bladder and head & neck cancers may benefit from increased surveillance and advice to avoid known risk factors.
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