Malignant rhabdoid tumor of the colon
Malignant rhabdoid tumor of the colon
复制标题
结肠恶性横纹肌样瘤
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
M. Tsao
中科院分区：
文献类型：
--
作者：
V. Marcus;J. Viloria;D. Owen;M. Tsao
目的：恶性横纹肌样瘤首先在肾脏中被描述为肾母细胞瘤的一种罕见变异，具有“横纹肌肉瘤样”模式，预后特别差。进一步的研究表明这些肿瘤是一种独特的临床病理实体。随后，在多个肾外部位发现了具有相似组织学外观的肿瘤，显示出“横纹肌样”细胞。方法：我们在此报告一例采用选定的分子技术研究的结肠恶性横纹肌瘤病例。结果和结论：该肿瘤表现出肾脏或肾外部位恶性横纹肌样肿瘤的几个不寻常的发现，包括流式细胞术分析的非整倍性和 p53 蛋白的核免疫组织化学染色阳性，这表明存在 p53 基因突变。然而，DNA 分析未能证明任何 theras 家族基因中存在点突变。
PURPOSE: Malignant rhabdoid tumors were first described in the kidney as a rare variant of Wilms' tumor with a “rhabdomyosarcomatoid” pattern and a particularly poor prognosis. Further studies have demonstrated these neoplasms as a distinct clinicopathologic entity. Subsequently, tumors with a similar histologic appearance, demonstrating the “rhabdoid” cells, have been found in a variety of extrarenal sites. METHODS: We report here a case of malignant rhabdoid tumor of the colon studied with selected molecular techniques. RESULTS AND CONCLUSIONS: This tumor demonstrated several unusual findings for malignant rhabdoid tumors of renal or extrarenal sites, including aneuploidy by flow cytometric analysis and a positive nuclear immunohistochemical staining for p53 protein, which suggests presence of p53 gene mutation. DNA analyses, however, failed to demonstrate the presence of point mutation in any of therasfamily genes.
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影响因子：
11.2
作者：
Joyce Bos
通讯作者：
Joyce Bos
影响因子：
11.2
作者：
Nabeel Bardeesy;J. Beckwith;Jerry Pelletier
通讯作者：
Nabeel Bardeesy;J. Beckwith;Jerry Pelletier
肾母细胞瘤中 p53 的突变。
DOI：
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发表时间：
1995
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
影响因子：
--
作者：
Takeuchi,S;Bartram,CR;Ludwig,R;Royer-Pokora,B;Schneider,S;Imamura,J;Koeffler,HP
通讯作者：
Koeffler,HP
DOI：
10.1001/archsurg.1990.01410210089014
发表时间：
1990
期刊：
Archives of surgery (Chicago, Ill. : 1960)
影响因子：
--
作者：
Meijer,S;Peretz,T;Gaynor,JJ;Tan,C;Hajdu,SI;Brennan,MF
通讯作者：
Brennan,MF