Exosomes as Novel Delivery Systems for Application in Traditional Chinese Medicine.
Exosomes as Novel Delivery Systems for Application in Traditional Chinese Medicine.
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DOI：
10.3390/molecules27227789
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发表时间：
2022-11-12
期刊：
影响因子：
--
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Chen Q;Wu D;Wang Y;Chen Z
外泌体作为来自各种细胞类型的自然礼物，直径范围为~40至160 nm，最近受到关注。它们由含有来自亲本细胞的不同成分（例如表面配体和受体）的脂质膜双层结构组成。外泌体起源于多种来源，具有参与多种生物过程的能力，包括细胞通讯的调节。由于其理想的天然结构和特性，外泌体被考虑作为药物递送系统（DDS）。它们可以在输送治疗剂方面提供深远的影响，具有很大的优势，包括特异性靶向、高生物相容性和无毒。此外，它们也可以被认为是改善天然化合物，传统中药（TCM）的主要成分，这通常是由于其结构的复杂性，稳定性差，作用机制不清楚而被忽视。本文综述了外泌体的分类以及基于外泌体的DDS在中医药治疗不同疾病中的研究进展。此外，本文还讨论了外泌体的优势和面临的挑战，以促进其进一步研究和应用。
Exosomes, as gifts of nature derived from various cell types with a size range from ~40 to 160 nm in diameter, have gained attention recently. They are composed of a lipid membrane bilayer structure containing different constituents, such as surface ligands and receptors, from the parental cells. Originating from a variety of sources, exosomes have the ability to participate in a diverse range of biological processes, including the regulation of cellular communication. On account of their ideal native structure and characteristics, exosomes are taken into account as drug delivery systems (DDSs). They can provide profound effects on conveying therapeutic agents with great advantages, including specific targeting, high biocompatibility, and non-toxicity. Further, they can also be considered to ameliorate natural compounds, the main constituents of traditional Chinese medicine (TCM), which are usually ignored due to the complexity of their structures, poor stability, and unclear mechanisms of action. This review summarizes the classification of exosomes as well as the research progress on exosome-based DDSs for the treatment of different diseases in TCM. Furthermore, this review discusses the advantages and challenges faced by exosomes to contribute to their further investigation and application.
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影响因子：
12.4
作者：
Bellavia D;Raimondo S;Calabrese G;Forte S;Cristaldi M;Patinella A;Memeo L;Manno M;Raccosta S;Diana P;Cirrincione G;Giavaresi G;Monteleone F;Fontana S;De Leo G;Alessandro R
通讯作者：
Alessandro R
DOI：
10.1186/s12964-022-00945-w
发表时间：
2022-09-12
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1007/s00109-006-0102-0
发表时间：
2006-12
期刊：
Journal of molecular medicine (Berlin, Germany)
影响因子：
--
作者：
Dai S;Zhou X;Wang B;Wang Q;Fu Y;Chen T;Wan T;Yu Y;Cao X
通讯作者：
Cao X
影响因子：
16
作者：
Arab, T.;Raffo-Romero, A.;Sautiere, P-E
通讯作者：
Sautiere, P-E
影响因子：
14.8
作者：
D'Acunzo, Pasquale;Kim, Yohan;Ungania, Jonathan M.;Perez-Gonzalez, Rocio;Goulbourne, Chris N.;Levy, Efrat
通讯作者：
Levy, Efrat