Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats.
Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats.
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耐药和易感大鼠小肠结肠炎中组织白细胞介素 1 和白细胞介素 1 受体拮抗剂的表达。
DOI：
10.1016/0016-5085(94)90755-2
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发表时间：
1994
期刊：
影响因子：
29.4
通讯作者：
Sartor,RB
中科院分区：
文献类型：
--
作者：
McCall,RD;Haskill,S;Zimmermann,EM;Lund,PK;Thompson,RC;Sartor,RB
Background/Aims:Subserosal injection of purified group A streptococcal peptidoglycan-polysaccharide (PG-APS) induces chronic relapsing granulomatous enterocolitis and systemic inflammation in susceptible inbred Lewis rats but only transient intestinal injury in Buffalo and Fischer rats. Cecal interleukin 1 (IL-1) and IL-1 receptor antagonist (IL-1ra) expression was measured in inbred rats displaying differential susceptibility to experimental enterocolitis.Methods:The ileum and cecum of Lewis, Buffalo, and Fischer rats were subserosally injected with purified PG-APS or albumin. IL-1 and IL-1ra messenger RNA (mRNA) and protein (IL-1 only) were measured 1 or 27 days later. PG-APS-injected Lewis rats were treated with recombinant human IL-1ra. Kinetics of IL-1 and IL-1ra mRNA expression were studied in peritoneal cells.Results:All rat strains developed acute inflammation with increased cecal concentrations of IL-1β and IL-1ra mRNA. Lewis rats developed chronic enterocolitis and had higher IL-1 and IL-1ra mRNA tissue levels than Buffalo or Fischer rats, which displayed no chronic inflammation. IL-1β and IL-1ra were produced by submucosal granulomas and correlated with inflammation. IL-1α protein levels paralleled IL-1β mRNA expression. IL-1ra treatment attenuated acute and chronic enterocolitis, adhesions, and arthritis. PG-APS induced IL-1 and IL-1ra expression in peritoneal cells from Lewis and Fischer rats.Conclusions:Bacterial cell wall polymers stimulate IL-1 and IL-1ra expression in vivo and in vitro. These counterbalancing cytokines are increased in experimental enterocolitis and have important immunoregulatory roles in intestinal inflammation.
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通过转化生长因子-β 诱导白细胞介素 1 受体拮抗蛋白
影响因子：
5.4
作者：
M. Turner;D. Chantry;P. Katsikis;A. Berge;F. Brennan;M. Feldmann
通讯作者：
M. Feldmann
影响因子：
20.3
作者：
C. Dinarello
通讯作者：
C. Dinarello
白介素1（IL-1）阻断对细胞因子合成的影响： 一、IL-1受体拮抗剂抑制IL-1诱导的细胞因子合成并阻断IL-1与其在人单核细胞上的II型受体的结合。
影响因子：
20.3
作者：
Granowitz,EV;Clark,BD;Vannier,E;Callahan,MV;Dinarello,CA
通讯作者：
Dinarello,CA
内毒素血症后，糖皮质激素不会减弱白细胞介素 1 受体拮抗剂的作用。
DOI：
10.1001/archsurg.1993.01420140015003
发表时间：
1993
期刊：
Archives of surgery (Chicago, Ill. : 1960)
影响因子：
--
作者：
Santos,AA;Scheltinga,MR;Lynch,E;Brown,EF;Lawton,P;Chambers,E;Browning,J;Dinarello,CA;Wolff,SM;Wilmore,DW
通讯作者：
Wilmore,DW
IL-1 和 IL-1 受体拮抗剂在子宫内膜癌中的表达。
影响因子：
4.7
作者：
L. Van Le;S. Haskill;G. Jaffe;W. Fowler
通讯作者：
W. Fowler