KeyPathwayMiner 4.0: condition-specific pathway analysis by combining multiple omics studies and networks with Cytoscape.

KeyPathwayMiner 4.0: condition-specific pathway analysis by combining multiple omics studies and networks with Cytoscape.
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DOI:
10.1186/s12918-014-0099-x
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发表时间:
2014-08-19
影响因子:
--
通讯作者:
Baumbach J
Baumbach J
中科院分区:
生物2区
文献类型:
--
作者:
Alcaraz N;Pauling J;Batra R;Barbosa E;Junge A;Christensen AG;Azevedo V;Ditzel HJ;Baumbach J

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在过去的十年中,网络富集分析在计算系统生物学中变得流行,以阐明异常的网络模块。传统上,这些方法侧重于将基因表达数据与蛋白质-蛋白质相互作用(PPI)网络相结合。如今,所谓的组学技术允许包含更多的数据集,例如蛋白质磷酸化或表观遗传修饰。这就产生了对分析方法的需求,该分析方法可以将这些不同的数据源联合收割机以获得关于异常生物网络的系统级视图。我们提出了一个新版本的KeyPathwayMiner(4.0版),它不仅限于分析单个组学数据集,例如基因表达,而且能够直接联合收割机几种不同的组学数据类型。版本4.0可以通过添加对包含(避免)正(负)列表中提供的基因的子网络的搜索偏好来进一步整合现有知识。最后,新版本现在还提供了一组新颖的可视化功能,并已作为标准生物信息学网络分析工具Cytoscape的应用程序实现。通过KeyPathwayMiner 4.0,我们发布了一个Cytoscape应用程序,用于基于多组学的子网络提取。它可以在Cytoscape的应用程序商店http://apps.cytoscape.org/apps/keypathwayminer或通过http://keypathwayminer.mpi-inf.mpg.de获得。
Over the last decade network enrichment analysis has become popular in computational systems biology to elucidate aberrant network modules. Traditionally, these approaches focus on combining gene expression data with protein-protein interaction (PPI) networks. Nowadays, the so-called omics technologies allow for inclusion of many more data sets, e.g. protein phosphorylation or epigenetic modifications. This creates a need for analysis methods that can combine these various sources of data to obtain a systems-level view on aberrant biological networks. We present a new release of KeyPathwayMiner (version 4.0) that is not limited to analyses of single omics data sets, e.g. gene expression, but is able to directly combine several different omics data types. Version 4.0 can further integrate existing knowledge by adding a search bias towards sub-networks that contain (avoid) genes provided in a positive (negative) list. Finally the new release now also provides a set of novel visualization features and has been implemented as an app for the standard bioinformatics network analysis tool: Cytoscape. With KeyPathwayMiner 4.0, we publish a Cytoscape app for multi-omics based sub-network extraction. It is available in Cytoscape’s app store http://apps.cytoscape.org/apps/keypathwayminer or via http://keypathwayminer.mpi-inf.mpg.de.
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