KeyPathwayMiner 4.0: condition-specific pathway analysis by combining multiple omics studies and networks with Cytoscape.
KeyPathwayMiner 4.0: condition-specific pathway analysis by combining multiple omics studies and networks with Cytoscape.
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DOI:
10.1186/s12918-014-0099-x
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发表时间:
2014-08-19
影响因子:
--
通讯作者:
Baumbach J
中科院分区:
文献类型:
--
作者:
Alcaraz N;Pauling J;Batra R;Barbosa E;Junge A;Christensen AG;Azevedo V;Ditzel HJ;Baumbach J
Over the last decade network enrichment analysis has become popular in computational systems biology to elucidate aberrant network modules. Traditionally, these approaches focus on combining gene expression data with protein-protein interaction (PPI) networks. Nowadays, the so-called omics technologies allow for inclusion of many more data sets, e.g. protein phosphorylation or epigenetic modifications. This creates a need for analysis methods that can combine these various sources of data to obtain a systems-level view on aberrant biological networks. We present a new release of KeyPathwayMiner (version 4.0) that is not limited to analyses of single omics data sets, e.g. gene expression, but is able to directly combine several different omics data types. Version 4.0 can further integrate existing knowledge by adding a search bias towards sub-networks that contain (avoid) genes provided in a positive (negative) list. Finally the new release now also provides a set of novel visualization features and has been implemented as an app for the standard bioinformatics network analysis tool: Cytoscape. With KeyPathwayMiner 4.0, we publish a Cytoscape app for multi-omics based sub-network extraction. It is available in Cytoscape’s app store http://apps.cytoscape.org/apps/keypathwayminer or via http://keypathwayminer.mpi-inf.mpg.de.
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影响因子:
14.9
作者:
Keshava Prasad TS;Goel R;Kandasamy K;Keerthikumar S;Kumar S;Mathivanan S;Telikicherla D;Raju R;Shafreen B;Venugopal A;Balakrishnan L;Marimuthu A;Banerjee S;Somanathan DS;Sebastian A;Rani S;Ray S;Harrys Kishore CJ;Kanth S;Ahmed M;Kashyap MK;Mohmood R;Ramachandra YL;Krishna V;Rahiman BA;Mohan S;Ranganathan P;Ramabadran S;Chaerkady R;Pandey A
通讯作者:
Pandey A
影响因子:
14.9
作者:
Sass, Steffen;Buettner, Florian;Theis, Fabian J.
通讯作者:
Theis, Fabian J.
影响因子:
--
作者:
Ulitsky I;Shamir R
通讯作者:
Shamir R
DOI:
10.1093/bioinformatics/btt138
发表时间:
2013-05-15
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
作者:
Lotia S;Montojo J;Dong Y;Bader GD;Pico AR
通讯作者:
Pico AR
影响因子:
64.8
作者:
Muzny, Donna M.;Bainbridge, Matthew N.;Chang, Kyle;Dinh, Huyen H.;Drummond, Jennifer A.;Fowler, Gerald;Kovar, Christie L.;Lewis, Lora R.;Morgan, Margaret B.;Newsham, Irene F.;Reid, Jeffrey G.;Santibanez, Jireh;Shinbrot, Eve;Trevino, Lisa R.;Wu, Yuan-Qing;Wang, Min;Gunaratne, Preethi;Donehower, Lawrence A.;Creighton, Chad J.;Wheeler, David A.;Gibbs, Richard A.;Lawrence, Michael S.;Voet, Douglas;Jing, Rui;Cibulskis, Kristian;Sivachenko, Andrey;Stojanov, Petar;McKenna, Aaron;Lander, Eric S.;Gabriel, Stacey;Getz, Gad;Ding, Li;Fulton, Robert S.;Koboldt, Daniel C.;Wylie, Todd;Walker, Jason;Dooling, David J.;Fulton, Lucinda;Delehaunty, Kim D.;Fronick, Catrina C.;Demeter, Ryan;Mardis, Elaine R.;Wilson, Richard K.;Chu, Andy;Chun, Hye-Jung E.;Mungall, Andrew J.;Pleasance, Erin;Robertson, A. Gordon;Stoll, Dominik;Balasundaram, Miruna;Birol, Inanc;Butterfield, Yaron S. N.;Chuah, Eric;Coope, Robin J. N.;Dhalla, Noreen;Guin, Ranabir;Hirst, Carrie;Hirst, Martin;Holt, Robert A.;Lee, Darlene;Li, Haiyan I.;Mayo, Michael;Moore, Richard A.;Schein, Jacqueline E.;Slobodan, Jared R.;Tam, Angela;Thiessen, Nina;Varhol, Richard;Zeng, Thomas;Zhao, Yongjun;Jones, Steven J. M.;Marra, Marco A.;Bass, Adam J.;Ramos, Alex H.;Saksena, Gordon;Cherniack, Andrew D.;Schumacher, Stephen E.;Tabak, Barbara;Carter, Scott L.;Pho, Nam H.;Nguyen, Huy;Onofrio, Robert C.;Crenshaw, Andrew;Ardlie, Kristin;Beroukhim, Rameen;Winckler, Wendy;Getz, Gad;Meyerson, Matthew;Protopopov, Alexei;Zhang, Juinhua;Hadjipanayis, Angela;Lee, Eunjung;Xi, Ruibin;Yang, Lixing;Ren, Xiaojia;Zhang, Hailei;Sathiamoorthy, Narayanan;Shukla, Sachet;Chen, Peng-Chieh;Haseley, Psalm;Xiao, Yonghong;Lee, Semin;Seidman, Jonathan;Chin, Lynda;Park, Peter J.;Kucherlapati, Raju;Auman, J. Todd;Hoadley, Katherine A.;Du, Ying;Wilkerson, Matthew D.;Shi, Yan;Liquori, Christina;Meng, Shaowu;Li, Ling;Turman, Yidi J.;Topal, Michael D.;Tan, Donghui;Waring, Scot;Buda, Elizabeth;Walsh, Jesse;Jones, Corbin D.;Mieczkowski, Piotr A.;Singh, Darshan;Wu, Junyuan;Gulabani, Anisha;Dolina, Peter;Bodenheimer, Tom;Hoyle, Alan P.;Simons, Janae V.;Soloway, Matthew;Mose, Lisle E.;Jefferys, Stuart R.;Balu, Saianand;O'Connor, Brian D.;Prins, Jan F.;Chiang, Derek Y.;Hayes, D. Neil;Perou, Charles M.;Hinoue, Toshinori;Weisenberger, Daniel J.;Maglinte, Dennis T.;Pan, Fei;Berman, Benjamin P.;Van den Berg, David J.;Shen, Hui;Triche, Timothy, Jr.;Baylin, Stephen B.;Laird, Peter W.;Getz, Gad;Noble, Michael;Voet, Doug;Saksena, Gordon;Gehlenborg, Nils;DiCara, Daniel;Zhang, Juinhua;Zhang, Hailei;Wu, Chang-Jiun;Liu, Spring Yingchun;Shukla, Sachet;Lawrence, Michael S.;Zhou, Lihua;Sivachenko, Andrey;Lin, Pei;Stojanov, Petar;Jing, Rui;Park, Richard W.;Nazaire, Marc-Danie;Robinson, Jim;Thorvaldsdottir, Helga;Mesirov, Jill;Park, Peter J.;Chin, Lynda;Thorsson, Vesteinn;Reynolds, Sheila M.;Bernard, Brady;Kreisberg, Richard;Lin, Jake;Iype, Lisa;Bressler, Ryan;Erkkilae, Timo;Gundapuneni, Madhumati;Liu, Yuexin;Norberg, Adam;Robinson, Tom;Da Yang;Zhang, Wei;Shmulevich, Ilya;De Ronde, Jorma J.;Schultz, Nikolaus;Cerami, Ethan;Ciriello, Giovanni;Goldberg, Arthur P.;Gross, Benjamin;Jacobsen, Anders;Gao, Jianjiong;Kaczkowski, Bogumil;Sinha, Rileen;Aksoy, B. Arman;Antipin, Yevgeniy;Reva, Boris;Shen, Ronglai;Taylor, Barry S.;Chan, Timothy A.;Ladanyi, Marc;Sander, Chris;Akbani, Rehan;Zhang, Nianxiang;Broom, Bradley M.;Casasent, Tod;Unruh, Anna;Wakefield, Chris;Hamilton, Stanley R.;Cason, R. Craig;Baggerly, Keith A.;Weinstein, John N.;Haussler, David;Benz, Christopher C.;Stuart, Joshua M.;Benz, Stephen C.;Sanborn, J. Zachary;Vaske, Charles J.;Zhu, Jingchun;Szeto, Christopher;Scott, Gary K.;Yau, Christina;Ng, Sam;Goldstein, Ted;Ellrott, Kyle;Collisson, Eric;Cozen, Aaron E.;Zerbino, Daniel;Wilks, Christopher;Craft, Brian;Spellman, Paul;Penny, Robert;Shelton, Troy;Hatfield, Martha;Morris, Scott;Yena, Peggy;Shelton, Candace;Sherman, Mark;Paulauskis, Joseph;Gastier-Foster, Julie M.;Bowen, Jay;Ramirez, Nilsa C.;Black, Aaron;Pyatt, Robert;Wise, Lisa;White, Peter;Bertagnolli, Monica;Brown, Jen;Chan, Timothy A.;Chu, Gerald C.;Czerwinski, Christine;Denstman, Fred;Dhir, Rajiv;Doerner, Arnulf;Fuchs, Charles S.;Guillem, Jose G.;Iacocca, Mary;Juhl, Hartmut;Kaufman, Andrew;Kohl, Bernard, III;Van Le, Xuan;Mariano, Maria C.;Medina, Elizabeth N.;Meyers, Michael;Nash, Garrett M.;Paty, Phillip B.;Petrelli, Nicholas;Rabeno, Brenda;Richards, William G.;Solit, David;Swanson, Pat;Temple, Larissa;Tepper, Joel E.;Thorp, Richard;Vakiani, Efsevia;Weiser, Martin R.;Willis, Joseph E.;Witkin, Gary;Zeng, Zhaoshi;Zinner, Michael J.;Zornig, Carsten;Jensen, Mark A.;Sfeir, Robert;Kahn, Ari B.;Chu, Anna L.;Kothiyal, Prachi;Wang, Zhining;Snyder, Eric E.;Pontius, Joan;Pihl, Todd D.;Ayala, Brenda;Backus, Mark;Walton, Jessica;Whitmore, Jon;Baboud, Julien;Berton, Dominique L.;Nicholls, Matthew C.;Srinivasan, Deepak;Raman, Rohini;Girshik, Stanley;Kigonya, Peter A.;Alonso, Shelley;Sanbhadti, Rashmi N.;Barletta, Sean P.;Greene, John M.;Pot, David A.;Shaw, Kenna R. Mills;Dillon, Laura A. L.;Buetow, Ken;Davidsen, Tanja;Demchok, John A.;Eley, Greg;Ferguson, Martin;Fielding, Peter;Schaefer, Carl;Sheth, Margi;Yang, Liming;Guyer, Mark S.;Ozenberger, Bradley A.;Palchik, Jacqueline D.;Peterson, Jane;Sofia, Heidi J.;Thomson, Elizabeth
通讯作者:
Thomson, Elizabeth