Imaging Techniques to Determine Degree of Sarcopenia and Systemic Inflammation in Advanced Renal Cell Carcinoma.
Imaging Techniques to Determine Degree of Sarcopenia and Systemic Inflammation in Advanced Renal Cell Carcinoma.
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DOI：
10.1007/s11934-023-01157-6
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发表时间：
2023-07
影响因子：
2.6
通讯作者：
Psutka, Sarah P.
中科院分区：
文献类型：
--
作者：
Schmeusser, Benjamin N.;Ali, Adil A.;Fintelmann, Florian J.;Garcia, Jose M.;Williams, Grant R.;Master, Viraj A.;Psutka, Sarah P.
关键词：
本综述的目的是提供有关肾细胞癌(RCC)中石棺减少和炎症作为预后因素的文献的最新了解。骨质疏松症越来越被认为是肾癌的一个预后因素。新出现的文献表明，在连续成像中监测肌肉数量和检查肌肉密度可能是额外的信息。炎症在肾癌中具有预后作用，也被认为是肾癌和骨质疏松症发生和发展的关键因素。最近的研究表明，当这两个预后因素联合使用时，可能会提供额外的预后能力。正在进行的研究包括有关骨质疏松症研究和成像的质量控制，提高对肌肉损失机制的理解，以及通过改进成像分析实用性(即人工智能)和可行的生物标志物来加强骨质疏松症的临床纳入。肾癌患者预后不良的相关因素是骨质疏松症和全身炎症。对高质量石棺减少评估、标准化和快速石棺减少评估的进一步研究有待于最终纳入这些预后因素的常规临床应用。
The purpose of this review is to provide an up-to-date understanding regarding the literature on sarcopenia and inflammation as prognostic factors in the context of renal cell carcinoma (RCC). Sarcopenia is increasingly recognized as a prognostic factor in RCC. Emerging literature suggests monitoring quantity of muscle on successive imaging and examining muscle density may be additionally informative. Inflammation has prognostic ability in RCC and is also considered a key contributor to development and progression of both RCC and sarcopenia. Recent studies suggest these two prognostic factors together may provide additional prognostic ability when used in combination. Ongoing developments include quality control regarding sarcopenia research and imaging, improving understanding of muscle loss mechanisms, and enhancing clinical incorporation of sarcopenia via improving imaging analysis practicality (i.e., artificial intelligence) and feasible biomarkers. Sarcopenia and systemic inflammation are complementary prognostic factors for adverse outcomes in patients with RCC. Further study on high-quality sarcopenia assessment standardization and expedited sarcopenia assessment is desired for eventual routine clinical incorporation of these prognostic factors.
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