Prognostic Significance of Pre- to Postoperative Dynamics of Sarcopenia for Patients with Renal Cell Carcinoma Undergoing Laparoscopic Nephrectomy.
Prognostic Significance of Pre- to Postoperative Dynamics of Sarcopenia for Patients with Renal Cell Carcinoma Undergoing Laparoscopic Nephrectomy.
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DOI：
10.3389/fsurg.2022.871731
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发表时间：
2022
影响因子：
1.8
通讯作者：
Chen, Ming
中科院分区：
文献类型：
--
作者：
Chen, Shuqiu;He, Ting;Sun, Si;Wu, Jianping;Xu, Bin;Mao, Weipu;Chen, Ming
本研究的目的是探讨肌肉减少症的动力学在肾细胞癌（RCC）患者接受腹腔镜肾切除术前后的预后作用。该研究纳入了2014年至2019年期间接受腹腔镜肾切除术的261例患者。L3腰椎区域的骨骼肌指数（SMI）用于评估肌肉减少症。根据从术前到术后的肌肉减少症动态将总体人群分为4组：组1（术前和术后肌肉减少症）、组2（术前非肌肉减少症到术后肌肉减少症）、组3（术前肌肉减少症到术后非肌肉减少症）和组4（术前和术后非肌肉减少症）。研究的终点是总生存期（OS）和癌症特异性生存期（CSS）。在261例接受腹腔镜肾切除术的患者中，103例（39.5%）术前有肌肉减少症，183例（70.1%）术后有肌肉减少症。术前或术后肌肉减少症患者的生存结局较差。与术前和术后肌肉减少相比，肌肉减少动态对RCC患者的OS（AUC = 0.737）和CSS（AUC = 0.696）有更好的预测作用，并且肌肉减少动态组4的患者具有最好的OS和CSS。此外，肌肉减少症动力学是OS和CSS的独立风险因素，OS风险降低94.5%（HR = 0.055，95% CI 0.007-0.407，p = 0.003）和CSS风险降低91.9%（HR = 0.081，95% CI 0.011-0.616，p = 0.015）。我们的研究是第一个评估肾细胞癌患者术前和术后肌肉减少动力学的预后价值。
The aim of this study was to investigate the prognostic role of the dynamics of sarcopenia in the pre- to postoperative for patients with renal cell carcinoma (RCC) undergoing laparoscopic nephrectomy. This study included 261 patients who underwent laparoscopic nephrectomy between 2014 and 2019. The skeletal muscle index (SMI) of the L3 lumbar region was used to assess sarcopenia. The overall population was divided into four groups according to the dynamics of sarcopenia from pre- to postoperative: group 1 (both pre- and postoperative sarcopenia), group 2 (preoperative non-sarcopenia to postoperative sarcopenia), group 3 (preoperative sarcopenia to postoperative non-sarcopenia), and group 4 (both pre- and postoperative non-sarcopenia). The endpoints of the study were overall survival (OS) and cancer-specific survival (CSS). Of the 261 patients who underwent laparoscopic nephrectomy, 103 (39.5%) had preoperative sarcopenia and 183 (70.1%) had postoperative sarcopenia. Patients with pre- or postoperative sarcopenia had poor survival outcomes. Sarcopenia dynamic was a better predictor of OS (AUC = 0.737) and CSS (AUC = 0.696) in patients with RCC than pre- and postoperative sarcopenia, and patients in group 4 of sarcopenia dynamic had the best OS and CSS. In addition, sarcopenia dynamics was an independent risk factor for OS and CSS, with a 94.5% reduction in OS risk (HR = 0.055, 95% CI 0.007–0.407, p = 0.003) and a 91.9% reduction in CSS risk (HR = 0.081, 95% CI 0.011–0.616, p = 0.015) in the group 4 compared with the group 1. Our study is the first to assess the prognostic value of pre- and postoperative sarcopenia dynamics in patients with RCC.
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DOI：
10.1007/s13539-010-0014-2
发表时间：
2010-12
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
von Haehling S;Morley JE;Anker SD
通讯作者：
Anker SD
影响因子：
6.6
作者：
Psutka, Sarah P.;Boorjian, Stephen A.;Tollefson, Matthew K.
通讯作者：
Tollefson, Matthew K.
DOI：
10.1093/gerona/glp183
发表时间：
2010-04-01
影响因子：
5.1
作者：
Giovannini, Silvia;Onder, Graziano;Landi, Francesco
通讯作者：
Landi, Francesco
影响因子：
6.6
作者：
Fukushima, Hiroshi;Nakanishi, Yasukazu;Koga, Fumitaka
通讯作者：
Koga, Fumitaka
影响因子：
28.4
作者：
Caan, Bette J.;Feliciano, Elizabeth M. Cespedes;Chen, Wendy Y.
通讯作者：
Chen, Wendy Y.